BAIAP2L1

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

Full Name

BAI1 Associated Protein 2 Like 1

Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

Biological Process

Actin crosslink formation Source: GO_Central
Actin filament bundle assembly Source: GO_Central
Plasma membrane organization Source: InterPro
Positive regulation of actin cytoskeleton reorganization Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Regulation of insulin receptor signaling pathway Source: InterPro
Response to bacterium Source: UniProtKB

Cellular Location

Cytoskeleton. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

PTM

Phosphorylated on tyrosine in response to insulin.