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Mouse Anti-BATF3 Recombinant Antibody (CBXS-2141) (CBMAB-S4905-CQ)

This product is a mouse antibody that recognizes BATF3. The antibody CBXS-2141 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all BATF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2141
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-19 at the N-terminus of SNFT of human origin.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BATF3
Introduction
This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.
Entrez Gene ID
55509
UniProt ID
Q9NR55
Alternative Names
Basic Leucine Zipper ATF-Like Transcription Factor 3; Basic Leucine Zipper Transcription Factor, ATF-Like 3; 21 KDa Small Nuclear Factor Isolated From T-Cells; Jun Dimerization Protein P21SNFT; Jun Dimerization Protein 1; B-ATF-3;
Function
AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).
Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
Biological Process
Dendritic cell differentiation Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to virus Source: UniProtKB
Cellular Location
Nucleus

Mamoor, S. (2021). BATF3 is differentially expressed in the lymph nodes of patients with metastatic breast cancer.

Luke, M. (2021). Predicting HBZ Interaction with BATF3 Enhancer Regions Through ChIP-seq​.

Li, P., Weng, Z., Li, P., Hu, F., Zhang, Y., Guo, Z., ... & Dai, S. (2021). BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis. Cancer Gene Therapy, 28(5), 400-412.

Zhu, D., Huang, R., Fu, P., Chen, L., Luo, L., Chu, P., ... & Wang, Y. (2019). Investigating the role of BATF3 in grass carp (Ctenopharyngodon idella) immune modulation: a fundamental functional analysis. International journal of molecular sciences, 20(7), 1687.

Lollies, A., Hartmann, S., Schneider, M., Bracht, T., Weiss, A. L., Arnolds, J., ... & Weniger, M. A. (2018). An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma. Leukemia, 32(1), 92-101.

Vrzalikova, K., Ibrahim, M., Vockerodt, M., Perry, T., Margielewska, S., Lupino, L., ... & Murray, P. G. (2018). S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells. Leukemia, 32(1), 214-223.

Cao, L., Liu, Y., Wang, D., Huang, L., Li, F., Liu, J., ... & Zhang, Y. (2018). MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling. Journal of Experimental & Clinical Cancer Research, 37(1), 1-14.

Weiser, C., Petkova, M. V., Rengstl, B., Döring, C., von Laer, D., Hartmann, S., ... & Newrzela, S. (2018). Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model. Oncotarget, 9(22), 15942.

Birth, P., Schöne, S., Stelzl, U., & Meijsing, S. H. (2017). Identification and characterization of BATF3 as a context-specific coactivator of the glucocorticoid receptor. PLoS One, 12(7), e0181219.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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