Mouse Anti-BATF3 Recombinant Antibody (CBYY-1759) (CBMAB-2108-YY)

Name: Mouse Anti-BATF3 Recombinant Antibody (CBYY-1759)
SKU: CBMAB-2108-YY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-BATF3 Recombinant Antibody (CBYY-1759) in FC

Expression of IRF4 and BATF3 in response to TNF signalling (24 h). Representative graphs of five independent donors, gates set using isotype controls for each antibody (Nuclear staining for IRF4, IRF8 and BATF3). ...View More

Sirvent, S., Vallejo, A. F., Davies, J., Clayton, K., Wu, Z., Woo, J., ... & Polak, M. E. (2020). Genomic programming of IRF4-expressing human Langerhans cells. Nature Communications, 11(1), 313.

Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYY-1759

Application

Immunogen

E. coli-derived recombinant human BATF3 Met1-Arg127.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
FC	2.5 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BATF3

Introduction

This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

Entrez Gene ID

55509

UniProt ID

Q9NR55

Alternative Names

Basic Leucine Zipper ATF-Like Transcription Factor 3; Basic Leucine Zipper Transcription Factor, ATF-Like 3; 21 KDa Small Nuclear Factor Isolated From T-Cells; Jun Dimerization Protein P21SNFT; Jun Dimerization Protein 1; B-ATF-3;

Function

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).
Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.

Biological Process

Dendritic cell differentiation Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to virus Source: UniProtKB

Cellular Location

Nucleus

Mamoor, S. (2021). BATF3 is differentially expressed in the lymph nodes of patients with metastatic breast cancer.

Luke, M. (2021). Predicting HBZ Interaction with BATF3 Enhancer Regions Through ChIP-seq.

Li, P., Weng, Z., Li, P., Hu, F., Zhang, Y., Guo, Z., ... & Dai, S. (2021). BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis. Cancer Gene Therapy, 28(5), 400-412.

Zhu, D., Huang, R., Fu, P., Chen, L., Luo, L., Chu, P., ... & Wang, Y. (2019). Investigating the role of BATF3 in grass carp (Ctenopharyngodon idella) immune modulation: a fundamental functional analysis. International journal of molecular sciences, 20(7), 1687.

Lollies, A., Hartmann, S., Schneider, M., Bracht, T., Weiss, A. L., Arnolds, J., ... & Weniger, M. A. (2018). An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma. Leukemia, 32(1), 92-101.

Vrzalikova, K., Ibrahim, M., Vockerodt, M., Perry, T., Margielewska, S., Lupino, L., ... & Murray, P. G. (2018). S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells. Leukemia, 32(1), 214-223.

Cao, L., Liu, Y., Wang, D., Huang, L., Li, F., Liu, J., ... & Zhang, Y. (2018). MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling. Journal of Experimental & Clinical Cancer Research, 37(1), 1-14.

Weiser, C., Petkova, M. V., Rengstl, B., Döring, C., von Laer, D., Hartmann, S., ... & Newrzela, S. (2018). Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model. Oncotarget, 9(22), 15942.

Birth, P., Schöne, S., Stelzl, U., & Meijsing, S. H. (2017). Identification and characterization of BATF3 as a context-specific coactivator of the glucocorticoid receptor. PLoS One, 12(7), e0181219.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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For research use only. Not intended for any clinical use.

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