Mouse Anti-BCAN Recombinant Antibody (S294A-6) (CBMAB-1194-CN)

Name: Mouse Anti-BCAN Recombinant Antibody (S294A-6)
SKU: CBMAB-1194-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

S294A-6

Application

WB, IF

Immunogen

Fusion protein amino acids 219-655 of rat Brevican.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.09% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Brevican

Introduction

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. The protein may play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Entrez Gene ID

25393

UniProt ID

P55068

Alternative Names

BEHAB; ALPBRE

Function

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Biological Process

Cell adhesion Source: InterPro
Central nervous system development Source: GO_Central
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Hippocampus development Source: Ensembl
Skeletal system development Source: GO_Central
Synapse maturation Source: Ensembl

Cellular Location

Isoform 1: Extracellular matrix
Isoform 2: Membrane

PTM

Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.

von Spreckelsen, N., Fadzen, C. M., Hartrampf, N., Ghotmi, Y., Wolfe, J. M., Dubey, S., ... & Cho, C. F. (2021). Targeting Glioblastoma Using a Novel Peptide Specific to a Deglycosylated Isoform of Brevican. Advanced Therapeutics, 4(4), 2000244.

Coate, T. M., & Conant, K. (2018). Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse. BMC biology, 16(1), 1-3.

Sonntag, M., Blosa, M., Schmidt, S., Reimann, K., Blum, K., Eckrich, T., ... & Morawski, M. (2018). Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets. BMC biology, 16(1), 1-18.

Favuzzi, E., Marques-Smith, A., Deogracias, R., Winterflood, C. M., Sánchez-Aguilera, A., Mantoan, L., ... & Rico, B. (2017). Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. Neuron, 95(3), 639-655.

Cho, C. F., Ghotmi, Y., Fazden, C., Wolfe, J., Bononi, F., Murrell, E., ... & Lawler, S. E. (2017). DDIS-19. Novel Peptide Homing to Glioma-Specific Isoform of Brevican Selectively Targets Malignant Brain Tumors. Neuro-oncology, 19(Suppl 6), vi62.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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