BCAN

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Full Name
Brevican
Function
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Biological Process
Cell adhesion Source: InterPro
Central nervous system development Source: GO_Central
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Hippocampus development Source: Ensembl
Skeletal system development Source: GO_Central
Synapse maturation Source: Ensembl
Cellular Location
Isoform 1: Extracellular matrix
Isoform 2: Membrane
PTM
Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.
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Anti-BCAN antibodies

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Mouse Anti-BCAN Recombinant Antibody (S294A-6) (CBMAB-1194-CN)

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Target: BCAN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: S294A-6
Application*: WB, IF
Datasheet SDS

Mouse Anti-BCAN Recombinant Antibody (450616) (CBMAB-1193-CN)

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Target: BCAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 450616
Application*: IC
Datasheet SDS

Mouse Anti-BCAN Recombinant Antibody (450613) (CBMAB-1192-CN)

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Target: BCAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 450613
Application*: WB, IP, B
Functional Assay
Datasheet SDS

Mouse Anti-BCAN Recombinant Antibody (CBLNB-122) (CBMAB-1191-CN)

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Target: BCAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat, Dog
Clone: CBLNB-122
Application*: WB, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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