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Mouse Anti-BCL2L10 Recombinant Antibody (CBYY-0410) (CBMAB-0412-YY)

This product is mouse antibody that recognizes BCL2L10. The antibody CBYY-0410 can be used for immunoassay techniques such as: WB
See all BCL2L10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0410
Antibody Isotype
IgG1
Application
ELISA, WB, FC, IF, IHC

Basic Information

Immunogen
Purified recombinant fragment of human BCL2L10 (AA: 31-186) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000
FC1:200-1:400
IF(ICC)1:200-1:1,000
IHC1:200-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2-like 10 (apoptosis facilitator)
Introduction
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forMouse a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.
Entrez Gene ID
UniProt ID
Alternative Names
BCL2 Like 10; BCL2-Like 10 (Apoptosis Facilitator); Anti-Apoptotic Protein NrH; Apoptosis Regulator Bcl-B; Bcl2-L-10; Death Inducer Binding To VBcl-2 And Apaf-1;
Function
Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245).
Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898).
Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898).
Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca2+ transfer to mitochondria which promotes apoptosis (PubMed:27995898).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ProtInc
Apoptotic process Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Female gamete generation Source: ProtInc
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: HGNC-UCL
Negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Spermatogenesis Source: ProtInc
Cellular Location
Nucleus membrane; Endoplasmic reticulum; Mitochondrion. Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898).
Topology
Helical: 183-200 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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