Mouse Anti-BEX3 Recombinant Antibody (4E5) (CBMAB-N0634-WJ)

Name: Mouse Anti-BEX3 Recombinant Antibody (4E5)
SKU: CBMAB-N0634-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4E5

Application

ELISA, WB

Immunogen

NGFRAP1 (AAH03190, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Brain Expressed X-Linked 3

Introduction

May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.

Entrez Gene ID

27018

UniProt ID

Q00994

Alternative Names

Brain Expressed X-Linked 3; Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1; Ovarian Granulosa Cell 13.0 KDa Protein HGR74; P75NTR-Associated Cell Death Executor; Brain-Expressed X-Linked Protein 3; DXS6984E; NGFRAP1;

Function

May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity).
May play an important role in the pathogenesis of neurogenetic diseases.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
Apoptotic process Source: UniProtKB-KW
Multicellular organism development Source: ProtInc
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
Regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
Signal transduction Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity).

do Amaral, M. J., Araujo, T. S., Díaz, N. C., Accornero, F., Polycarpo, C. R., Cordeiro, Y., ... & Almeida, M. S. (2020). Phase separation and disorder-to-order transition of human brain expressed X-Linked 3 (hBEX3) in the presence of small fragments of tRNA. Journal of molecular biology, 432(7), 2319-2348.

Navas-Pérez, E., Vicente-García, C., Mirra, S., Burguera, D., Fernàndez-Castillo, N., Ferrán, J. L., ... & Garcia-Fernàndez, J. (2020). Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Genome biology, 21(1), 1-27.

Gao, W., Li, J. Z. H., Chen, S. Q., Chu, C. Y., Chan, J. Y. W., & Wong, T. S. (2017). BEX 3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma. Cancer medicine, 6(2), 439-451.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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