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Mouse Anti-BIN3 Recombinant Antibody (CBYY-0592) (CBMAB-0595-YY)

This product is mouse antibody that recognizes BIN3. The antibody CBYY-0592 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all BIN3 antibodies
Published Data
Mouse Anti-BIN3 Recombinant Antibody (CBYY-0592) (CBMAB-0595-YY) in Immunoblot
Immunoblot of the indicated proteins in GBM12 treated with EGFR ligands. ...View More
Guo, G., Gong, K., Beckley, N., Zhang, Y., Yang, X., Chkheidze, R., ... & Habib, A. A. (2022). EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation. Nature cell biology, 24(8), 1291-1305.
Mouse Anti-BIN3 Recombinant Antibody (CBYY-0592) (CBMAB-0595-YY) in WB
BIN3 overexpression in cells was analyzed by Western blot. ...View More
Guo, G., Gong, K., Beckley, N., Zhang, Y., Yang, X., Chkheidze, R., ... & Habib, A. A. (2022). EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation. Nature cell biology, 24(8), 1291-1305.
Mouse Anti-BIN3 Recombinant Antibody (CBYY-0592) (CBMAB-0595-YY) in Immunoblot
Immunoblot of immunoprecipitated extracts from cellstreated with HGF for 24 hours. ...View More
Guo, G., Gong, K., Beckley, N., Zhang, Y., Yang, X., Chkheidze, R., ... & Habib, A. A. (2022). EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation. Nature cell biology, 24(8), 1291-1305.
Mouse Anti-BIN3 Recombinant Antibody (CBYY-0592) (CBMAB-0595-YY) in WB
Confirmation of three DE proteins in aMPV/C-infected Vero cells by Western blot analysis. The ratios of DE proteins in iTraq and Western blots are shown in the table on the right. ...View More
Guo, G., Gong, K., Beckley, N., Zhang, Y., Yang, X., Chkheidze, R., ... & Habib, A. A. (2022). EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation. Nature cell biology, 24(8), 1291-1305.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0592
Antibody Isotype
IgG1, κ
Application
IP, ELISA, WB, IF

Basic Information

Immunogen
Amino acids 159-253 mapping at the C-terminus of BIN3 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
bridging integrator 3
Introduction
The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.
Entrez Gene ID
55909
UniProt ID
Q9NQY0
Alternative Names
Bridging Integrator 3;
Function
Involved in cytokinesis and septation where it has a role in the localization of F-actin.
Biological Process
Actin cortical patch localization Source: GO_Central
Actin filament organization Source: UniProtKB
Cytoskeleton-dependent cytokinesis Source: UniProtKB
Division septum assembly Source: UniProtKB-KW
Endocytosis Source: GO_Central
Myoblast migration involved in skeletal muscle regeneration Source: Ensembl
Plasma membrane tubulation Source: GO_Central
Protein localization Source: UniProtKB
Regulation of lamellipodium assembly Source: Ensembl
Skeletal muscle fiber development Source: Ensembl
Unidimensional cell growth Source: UniProtKB
Cellular Location
Cytoskeleton
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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