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Mouse Anti-BirA Recombinant Antibody (5B11c3-3) (CBMAB-AP638LY)


See all BirA antibodies

Summary

Host Animal
Mouse
Specificity
E.coli
Clone
5B11c3-3
Antibody Isotype
IgG1, κ
Application
IF, WB

Basic Information

Immunogen
Amino acids residues 151-321 of E.coli BirA.
Host Species
Mouse
Specificity
E.coli
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BirA
Function
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
Biological Process
Biotin biosynthetic process Source: EcoliWiki
Biotin metabolic process Source: CAFA
Protein biotinylation Source: CACAO
Regulation of transcription, DNA-templated Source: UniProtKB-UniRule
Cellular Location
Cytoplasm; Transcription repressor complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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