BirA

BirA

Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.

Biotin biosynthetic process Source: EcoliWiki
Biotin metabolic process Source: CAFA
Protein biotinylation Source: CACAO
Regulation of transcription, DNA-templated Source: UniProtKB-UniRule

Cytoplasm; Transcription repressor complex