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Mouse Anti-BLMH Recombinant Antibody (4A2) (CBMAB-A0798-LY)

The product is antibody recognizes BLMH. The antibody 4A2 immunoassay techniques such as: WB, ELISA.
See all BLMH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
BLMH (NP_000377, 356 a.a. ~ 454 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Bleomycin Hydrolase
Introduction
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq]
Entrez Gene ID
642
UniProt ID
Q13867
Alternative Names
BH; BMH
Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Biological Process
Homocysteine catabolic process Source: GO_Central
Protein polyubiquitination Source: Reactome
Proteolysis Source: ProtInc
Response to drug Source: Ensembl
Response to toxic substance Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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