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Mouse Anti-BLMH Recombinant Antibody (CBYY-1943) (CBMAB-2292-YY)

This product is mouse antibody that recognizes BLMH. The antibody CBYY-1943 can be used for immunoassay techniques such as: Dot, WB
See all BLMH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1943
Antibody Isotype
IgG2b
Application
Dot, WB

Basic Information

Immunogen
BLMH antibody was raised in mouse using recombinant Human Bleomycin Hydrolase (Blmh)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bleomycin Hydrolase
Introduction
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
Entrez Gene ID
642
UniProt ID
Q13867
Alternative Names
Bleomycin Hydrolase; BLM Hydrolase; EC 3.4.22.40; BMH; BH;
Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Biological Process
Homocysteine catabolic process Source: GO_Central
Protein polyubiquitination Source: Reactome
Proteolysis Source: ProtInc
Response to drug Source: Ensembl
Response to toxic substance Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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