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Mouse Anti-BMP1 (AA 35-84) Recombinant Antibody (CBYY-0655) (CBMAB-0658-YY)

This product is mouse antibody that recognizes BMP1. The antibody CBYY-0655 can be used for immunoassay techniques such as: WB, IF
See all BMP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0655
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 225-617 of human BMP1(NP_001190) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 35-84

Target

Full Name
Bone Morphogenetic Protein 1
Introduction
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
Entrez Gene ID
649
UniProt ID
P13497
Alternative Names
Bone Morphogenetic Protein 1; Procollagen C-Endopeptidase; Mammalian Tolloid Protein; EC 3.4.24.19; PCOLC; PCP; Procollagen C-Proteinase 3; Procollagen C-Proteinase;
Function
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546).
Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:33169406, PubMed:32636307).
Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546).
Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307).
Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7.
Biological Process
Cartilage condensation Source: ProtInc
Cell differentiation Source: UniProtKB-KW
Collagen fibril organization Source: Reactome
Extracellular matrix disassembly Source: Reactome
High-density lipoprotein particle assembly Source: Reactome
Multicellular organism development Source: ProtInc
Ossification Source: UniProtKB-KW
Positive regulation of cartilage development Source: MGI
Proteolysis Source: UniProtKB
Skeletal system development Source: ProtInc
Cellular Location
Trans-Golgi network; Extracellular matrix; Secreted. Co-localizes with POSTN in the Golgi.
Isoform BMP1-3: Secreted
Involvement in disease
Osteogenesis imperfecta 13 (OI13): An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both upper and lower limbs.
PTM
Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.

Rafi, J. H., Jafar, T., Pathan, M. T., Reza, R., Islam, S., Sourna, I. J., ... & Ahammad, F. (2021). High expression of bone morphogenetic protein 1 (BMP1) is associated with a poor survival rate in human gastric cancer, a dataset approaches. Genomics, 113(1), 1141-1154.

Wang, J., Xie, X., Muench, N. A., Massoudi, D., Xu, C., Greenspan, D. S., & Feng, J. Q. (2021). Proteinase bone morphogenetic protein 1, but not tolloid‐like 1, plays a dominant role in maintaining periodontal homeostasis. Journal of Periodontology, 92(7), 1018-1029.

Strøm, T. B., Bjune, K., & Leren, T. P. (2020). Bone morphogenetic protein 1 cleaves the linker region between ligand-binding repeats 4 and 5 of the LDL receptor and makes the LDL receptor non-functional. Human molecular genetics, 29(8), 1229-1238.

Eshed-Eisenbach, Y., Devaux, J., Vainshtein, A., Golani, O., Lee, S. J., Feinberg, K., ... & Peles, E. (2020). Precise spatiotemporal control of nodal Na+ channel clustering by bone morphogenetic protein-1/Tolloid-like proteinases. Neuron, 106(5), 806-815.

Su, Z., He, L., Shang, H., Dai, T., Xu, F., & Zhao, J. (2020). Overexpression of Bone Morphogenetic Protein-1 Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells In Vitro. Medical science monitor: international medical journal of experimental and clinical research, 26, e920122-1.

Banerjee, S., Andrew, R. J., Duff, C. J., Fisher, K., Jackson, C. D., Lawrence, C. B., ... & Hooper, N. M. (2019). Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake. Scientific reports, 9(1), 1-14.

Rosell-Garcia, T., & Rodríguez-Pascual, F. (2018). Enhancement of collagen deposition and cross-linking by coupling lysyl oxidase with bone morphogenetic protein-1 and its application in tissue engineering. Scientific reports, 8(1), 1-12.

Kallander, L. S., Washburn, D., Hilfiker, M. A., Eidam, H. S., Lawhorn, B. G., Prendergast, J., ... & Willette, B. (2018). Reverse hydroxamate inhibitors of bone morphogenetic protein 1. ACS medicinal chemistry letters, 9(7), 736-740.

Hsieh, Y. Y., Tung, S. Y., Pan, H. Y., Yen, C. W., Xu, H. W., Deng, Y. F., ... & Li, C. (2018). Upregulation of bone morphogenetic protein 1 is associated with poor prognosis of late-stage gastric Cancer patients. BMC cancer, 18(1), 1-13.

Zhang, H., Jani, P., Liang, T., Lu, Y., & Qin, C. (2017). Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of molecular histology, 48(2), 83-98.

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For research use only. Not intended for any clinical use.

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