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Recombinant Mouse Anti-BMP15 Recombinant Antibody (28A) (CBMAB-XB0101-YC)

Provided herein is a Mouse Recombinant Antibody against Bone Morphogenetic Protein 15. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all BMP15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
28A
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recognizes sequence SAEVTASSSKHSGPENNQC on the C-terminus of human GDF9B (BMP15)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bone Morphogenetic Protein 15
Introduction
BMP15 is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.
Entrez Gene ID
9210
UniProt ID
O95972
Alternative Names
Bone Morphogenetic Protein 15; Growth/Differentiation Factor 9B; GDF9B; BMP-15; GDF-9B; ODG2; POF4;
Function
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Biological Process
BMP signaling pathway Source: GO_Central
Cellular protein metabolic process Source: Reactome
Female gamete generation Source: ProtInc
Granulosa cell development Source: InterPro
Ovarian follicle development Source: InterPro
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Positive regulation of transcription, DNA-templated Source: Ensembl
Post-translational protein modification Source: Reactome
SMAD protein signal transduction Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Ovarian dysgenesis 2 (ODG2): A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
Premature ovarian failure 4 (POF4): An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Flossmann, G., Wurmser, C., Pausch, H., Tenghe, A., Dodenhoff, J., Dahinten, G., ... & Fries, R. (2021). A nonsense mutation of bone morphogenetic protein-15 (BMP15) causes both infertility and increased litter size in pigs. BMC genomics, 22(1), 1-9.

Najafabadi, H. A., Khansefid, M., Mahmoud, G. G., Haruna, I. L., Zhou, H., & Hickford, J. G. (2021). Identification of sequence variation in the oocyte-derived bone morphogenetic protein 15 (BMP15) gene (BMP15) associated with litter size in New Zealand sheep (Ovis aries) breeds. Molecular Biology Reports, 1-8.

Faiza, H., Khan, M., Rafiq, M., Khan, A. A., Rind, N. A., & Naqvi, S. H. A. (2021). Two novel mutations in exon 2 of bone morphogenetic protein (BMP) 15 gene in Pakistani infertile females. Saudi Journal of Biological Sciences, 28(9), 5364-5370.

Taheri, M., Saki, G., Nikbakht, R., & Eftekhari, A. R. (2021). Bone morphogenetic protein 15 induces differentiation of mesenchymal stem cells derived from human follicular fluid to oocyte‐like cell. Cell Biology International, 45(1), 127-139.

Yu, H., Wang, Y., Wang, M., Liu, Y., Cheng, J., & Zhang, Q. (2020). Growth differentiation factor 9 (gdf9) and bone morphogenetic protein 15 (bmp15) are potential intraovarian regulators of steroidogenesis in Japanese flounder (Paralichthys olivaceus). General and Comparative Endocrinology, 297, 113547.

Coelho, L. A., do Carmo Buonfiglio, D., Kuwabara, W. M. T., Andrade-Silva, J., Gomes, P. R. L., Scialfa, J. H., ... & Cipolla-Neto, J. (2020). Melatonin regulates the expression of Bone Morphogenetic Protein 15 (Bmp-15), Growth Differentiation Factor 9 (Gdf-9) and LH receptor (Lhr) genes in developing follicles of rats. Melatonin Research, 3(4), 515-533.

Tang, T., Lin, Q., Qin, Y., Liang, X., Guo, Y., Cong, P., ... & He, Z. (2020). Effects of bone morphogenetic protein 15 (BMP15) knockdown on porcine testis morphology and spermatogenesis. Reproduction, Fertility and Development, 32(11), 999-1011.

Garcia, P., Aspee, K., Ramirez, G., Dettleff, P., Palomino, J., Peralta, O. A., ... & De los Reyes, M. (2019). Influence of growth differentiation factor 9 and bone morphogenetic protein 15 on in vitro maturation of canine oocytes. Reproduction in Domestic Animals, 54(2), 373-380.

Qin, Y., Tang, T., Li, W., Liu, Z., Yang, X., Shi, X., ... & He, Z. (2019). Bone morphogenetic protein 15 knockdown inhibits porcine ovarian follicular development and ovulation. Frontiers in cell and developmental biology, 7, 286.

Nagdy, H., Mahmoud, K. G. M., Kandiel, M. M., Helmy, N. A., Ibrahim, S. S., Nawito, M. F., & Othman, O. E. (2018). PCR-RFLP of bone morphogenetic protein 15 (BMP15/FecX) gene as a candidate for prolificacy in sheep. International journal of veterinary science and medicine, 6(sup1), S68-S72.

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For research use only. Not intended for any clinical use.

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