Rabbit Anti-BMP15 Recombinant Antibody (CBYY-0658) (CBMAB-0661-YY)

Name: Rabbit Anti-BMP15 Recombinant Antibody (CBYY-0658)
SKU: CBMAB-0661-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYY-0658

Application

WB, F, IH

Immunogen

Recombinant protein within Human BMP15 aa 270-392.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000
IHC	1:200
FC	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

TBS, pH 7.4, 40% glycerol, 0.05% BSA

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Bone Morphogenetic Protein 15

Introduction

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]

Entrez Gene ID

Human	9210
Mouse	12155
Rat	59302

UniProt ID

Human	O95972
Mouse	Q9Z0L4
Rat	Q9WUW1

Alternative Names

Bovinene Morphogenetic Protein 15; Growth/Differentiation Factor 9B; GDF9B; BMP-15; GDF-9B; ODG2; POF4;

Function

May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.

Biological Process

BMP signaling pathway Source: GO_Central
Cellular protein metabolic process Source: Reactome
Female gamete generation Source: ProtInc
Granulosa cell development Source: InterPro
Ovarian follicle development Source: InterPro
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Positive regulation of transcription, DNA-templated Source: Ensembl
Post-translational protein modification Source: Reactome
SMAD protein signal transduction Source: GO_Central

Cellular Location

Secreted

Involvement in disease

Ovarian dysgenesis 2 (ODG2): A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
Premature ovarian failure 4 (POF4): An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Flossmann, G., Wurmser, C., Pausch, H., Tenghe, A., Dodenhoff, J., Dahinten, G., ... & Fries, R. (2021). A nonsense mutation of bone morphogenetic protein-15 (BMP15) causes both infertility and increased litter size in pigs. BMC genomics, 22(1), 1-9.

Najafabadi, H. A., Khansefid, M., Mahmoud, G. G., Haruna, I. L., Zhou, H., & Hickford, J. G. (2021). Identification of sequence variation in the oocyte-derived bone morphogenetic protein 15 (BMP15) gene (BMP15) associated with litter size in New Zealand sheep (Ovis aries) breeds. Molecular Biology Reports, 1-8.

Faiza, H., Khan, M., Rafiq, M., Khan, A. A., Rind, N. A., & Naqvi, S. H. A. (2021). Two novel mutations in exon 2 of bone morphogenetic protein (BMP) 15 gene in Pakistani infertile females. Saudi Journal of Biological Sciences, 28(9), 5364-5370.

Taheri, M., Saki, G., Nikbakht, R., & Eftekhari, A. R. (2021). Bone morphogenetic protein 15 induces differentiation of mesenchymal stem cells derived from human follicular fluid to oocyte‐like cell. Cell Biology International, 45(1), 127-139.

Yu, H., Wang, Y., Wang, M., Liu, Y., Cheng, J., & Zhang, Q. (2020). Growth differentiation factor 9 (gdf9) and bone morphogenetic protein 15 (bmp15) are potential intraovarian regulators of steroidogenesis in Japanese flounder (Paralichthys olivaceus). General and Comparative Endocrinology, 297, 113547.

Coelho, L. A., do Carmo Buonfiglio, D., Kuwabara, W. M. T., Andrade-Silva, J., Gomes, P. R. L., Scialfa, J. H., ... & Cipolla-Neto, J. (2020). Melatonin regulates the expression of Bone Morphogenetic Protein 15 (Bmp-15), Growth Differentiation Factor 9 (Gdf-9) and LH receptor (Lhr) genes in developing follicles of rats. Melatonin Research, 3(4), 515-533.

Tang, T., Lin, Q., Qin, Y., Liang, X., Guo, Y., Cong, P., ... & He, Z. (2020). Effects of bone morphogenetic protein 15 (BMP15) knockdown on porcine testis morphology and spermatogenesis. Reproduction, Fertility and Development, 32(11), 999-1011.

Garcia, P., Aspee, K., Ramirez, G., Dettleff, P., Palomino, J., Peralta, O. A., ... & De los Reyes, M. (2019). Influence of growth differentiation factor 9 and bone morphogenetic protein 15 on in vitro maturation of canine oocytes. Reproduction in Domestic Animals, 54(2), 373-380.

Qin, Y., Tang, T., Li, W., Liu, Z., Yang, X., Shi, X., ... & He, Z. (2019). Bone morphogenetic protein 15 knockdown inhibits porcine ovarian follicular development and ovulation. Frontiers in cell and developmental biology, 7, 286.

Nagdy, H., Mahmoud, K. G. M., Kandiel, M. M., Helmy, N. A., Ibrahim, S. S., Nawito, M. F., & Othman, O. E. (2018). PCR-RFLP of bone morphogenetic protein 15 (BMP15/FecX) gene as a candidate for prolificacy in sheep. International journal of veterinary science and medicine, 6(sup1), S68-S72.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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