Sign in or Register   Sign in or Register
  |  

Mouse Anti-BMP2K Recombinant Antibody (CBYY-0663) (CBMAB-0666-YY)

This product is mouse antibody that recognizes BMP2K. The antibody CBYY-0663 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all BMP2K antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0663
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BMP2 inducible kinase
Introduction
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforMouse have been found for this gene.
Entrez Gene ID
55589
UniProt ID
Q9NSY1
Alternative Names
BMP2 Inducible Kinase; EC 2.7.11.1; BIKE; BMP-2-Inducible Protein Kinase; HRIHFB2017;
Function
May be involved in osteoblast differentiation.
Biological Process
Positive regulation of Notch signaling pathway Source: GO_Central
Protein phosphorylation Source: GO_Central
Regulation of bone mineralization Source: GO_Central
Regulation of clathrin-dependent endocytosis Source: GO_Central
Cellular Location
Nucleus
PTM
Autophosphorylated.

Ramesh, S. T., Navyasree, K. V., Sah, S., Ashok, A. B., Qathoon, N., Mohanty, S., ... & Umasankar, P. K. (2021). BMP2K phosphorylates AP‐2 and regulates clathrin‐mediated endocytosis. Traffic.

Cendrowski, J., & Miaczynska, M. (2020). Splicing variants of an endocytic regulator, BMP2K, differentially control autophagic degradation in erythroid cells. Autophagy, 16(12), 2303-2304.

Cendrowski, J., Kaczmarek, M., Mazur, M., Kuzmicz-Kowalska, K., Jastrzebski, K., Brewinska-Olchowik, M., ... & Miaczynska, M. (2020). Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Elife, 9, e58504.

Wang, M., Zhang, T., Zhang, X., Jiang, Z., Peng, M., & Huang, Z. (2020). BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia. Cell & bioscience, 10(1), 1-14.

Ramesh, S. T., Navyasree, K. V., Ashok, A. B., Qathoon, N., Mohanty, S., Swain, R. K., & Umasankar, P. K. (2019). Allosteric feed-forward activation of AP-2 via FCHO-BMP2K axis promotes clathrin-mediated endocytosis. bioRxiv, 870899.

Wells, C., Counago, R. M., Limas, J. C., Almeida, T. L., Cook, J. G., Drewry, D. H., ... & Axtman, A. D. (2019). SGC-AAK1-1: a chemical probe targeting AAK1 and BMP2K. ACS medicinal chemistry letters, 11(3), 340-345.

Zhao, L., Zhou, Z., Wang, S., Jiao, Q., Wu, J., Ma, F., ... & Ying, H. (2017). A recurrent mutation in bone morphogenetic proteins-2-inducible kinase gene is associated with developmental dysplasia of the hip. Experimental and therapeutic medicine, 13(5), 1773-1778.

Engman, S. I., Nelson, N. R., Dong, S., Graves, L. M., & Wauson, E. M. (2017). Inhibition of BMP2‐Inducible Kinase (BMP2K) Reduces Hypoxia/Reoxygenation Injury and Decreases Autophagic Flux in H9c2 Cells. The FASEB Journal, 31, lb540-lb540.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BMP2K Recombinant Antibody (CBYY-0663)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare