Mouse Recombinant BMP2K, Active protein, GST Tag (V2LY-0526-LY7875)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Mouse
Tag
GST Tag
Protein Construction
This product is Mouse Recombinant BMP2K, Active protein, GST Tag consist of Amino Acid: 1-422 and predicts a molecular mass of 70 kDa.
Molecule Mass
70 kDa
Sequence
Amino Acid: 1-422
Species
Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
BMP2 inducible kinase
Function
May be involved in osteoblast differentiation.
Biological Process
Positive regulation of Notch signaling pathway Source: GO_Central
Protein phosphorylation Source: GO_Central
Regulation of bone mineralization Source: GO_Central
Regulation of clathrin-dependent endocytosis Source: GO_Central
Cellular Location
Nucleus
PTM
Autophosphorylated.

Ramesh, S. T., Navyasree, K. V., Sah, S., Ashok, A. B., Qathoon, N., Mohanty, S., ... & Umasankar, P. K. (2021). BMP2K phosphorylates AP‐2 and regulates clathrin‐mediated endocytosis. Traffic.

Cendrowski, J., & Miaczynska, M. (2020). Splicing variants of an endocytic regulator, BMP2K, differentially control autophagic degradation in erythroid cells. Autophagy, 16(12), 2303-2304.

Cendrowski, J., Kaczmarek, M., Mazur, M., Kuzmicz-Kowalska, K., Jastrzebski, K., Brewinska-Olchowik, M., ... & Miaczynska, M. (2020). Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Elife, 9, e58504.

Wang, M., Zhang, T., Zhang, X., Jiang, Z., Peng, M., & Huang, Z. (2020). BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia. Cell & bioscience, 10(1), 1-14.

Ramesh, S. T., Navyasree, K. V., Ashok, A. B., Qathoon, N., Mohanty, S., Swain, R. K., & Umasankar, P. K. (2019). Allosteric feed-forward activation of AP-2 via FCHO-BMP2K axis promotes clathrin-mediated endocytosis. bioRxiv, 870899.

Wells, C., Counago, R. M., Limas, J. C., Almeida, T. L., Cook, J. G., Drewry, D. H., ... & Axtman, A. D. (2019). SGC-AAK1-1: a chemical probe targeting AAK1 and BMP2K. ACS medicinal chemistry letters, 11(3), 340-345.

Zhao, L., Zhou, Z., Wang, S., Jiao, Q., Wu, J., Ma, F., ... & Ying, H. (2017). A recurrent mutation in bone morphogenetic proteins-2-inducible kinase gene is associated with developmental dysplasia of the hip. Experimental and therapeutic medicine, 13(5), 1773-1778.

Engman, S. I., Nelson, N. R., Dong, S., Graves, L. M., & Wauson, E. M. (2017). Inhibition of BMP2‐Inducible Kinase (BMP2K) Reduces Hypoxia/Reoxygenation Injury and Decreases Autophagic Flux in H9c2 Cells. The FASEB Journal, 31, lb540-lb540.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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