BMP2K

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

BMP2 inducible kinase

May be involved in osteoblast differentiation.

Positive regulation of Notch signaling pathway Source: GO_Central
Protein phosphorylation Source: GO_Central
Regulation of bone mineralization Source: GO_Central
Regulation of clathrin-dependent endocytosis Source: GO_Central

Nucleus

Autophosphorylated.