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Mouse Anti-BMP3 Recombinant Antibody (CBLNB-130) (CBMAB-1216-CN)


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Published Data
CBMAB-1216-CN-1
CBMAB-1216-CN in IF
Representative immunofluorescence staining images and quantification of the number of PCs90 (Calbindin, green), the integrated intensity of granule cells (GCs), and the integrated intensity of 91 Bergmann glial cells (BGCs, Gdf10, red). ...View More
Wang, F., Wang, Q., Liu, B., Mei, L., Ma, S., Wang, S., ... & Song, X. (2021). The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum. Cell Death & Differentiation, 28(9), 2634-2650.
CBMAB-1216-CN-2
CBMAB-1216-CN in WB
Protein levels of BMP3, β-catenin, and β-actin were assessed by western blot analysis. ...View More
Kokabu, S., & Rosen, V. (2018). BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling. FEBS Open Bio, 8(2), 168-176.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle, Dog
Clone
CBLNB-130
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 363-435 of BMP-3 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Cattle, Dog
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bone Morphogenetic Protein 3
Introduction
Bone morphogenetic protein 3 (BMP30) is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. BMP30 is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands.
Entrez Gene ID
651
UniProt ID
P12645
Alternative Names
BMP-3A
Function
Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification (PubMed:11138004, PubMed:15269709).
Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways (PubMed:31665064).
Biological Process
Cartilage development Source: UniProtKB-KW
Cell-cell signaling Source: ProtInc
Osteoblast differentiation Source: InterPro
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Skeletal system development Source: ProtInc
SMAD protein signal transduction Source: GO_Central
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

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