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Mouse Anti-BMP7 Recombinant Antibody (M1-F8) (CBMAB-A0831-LY)

The product is antibody recognizes BMP7. The antibody M1-F8 immunoassay techniques such as: ELISA.
See all BMP7 antibodies
Published Data
Fig.1 Downregulation of BMP-7 expression during EMT of MC.
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Fig.2 BMP7 protein expression was assessed by immunoblotting analyzes.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
M1-F8
Antibody Isotype
IgG2b, κ
Application
E

Basic Information

Immunogen
BMP7 (NP_001710, 293 a.a. ~ 390 a.a) full length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Bone Morphogenetic Protein 7
Introduction
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq]
Entrez Gene ID
655
UniProt ID
P18075
Alternative Names
OP-1
Biological Process
Allantois development Source: Ensembl
Axon guidance Source: Ensembl
BMP signaling pathway Source: Ensembl
Branching involved in salivary gland morphogenesis Source: Ensembl
Branching morphogenesis of an epithelial tube Source: Ensembl
Cardiac muscle tissue development Source: Ensembl
Cardiac septum morphogenesis Source: Ensembl
Chorio-allantoic fusion Source: Ensembl
Embryonic camera-type eye morphogenesis Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Embryonic pattern specification Source: Ensembl
Embryonic skeletal joint morphogenesis Source: Ensembl
Endocardial cushion formation Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Heart trabecula morphogenesis Source: Ensembl
Hindbrain development Source: Ensembl
Mesoderm formation Source: Ensembl
Metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
Metanephric mesenchyme morphogenesis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of prostatic bud formation Source: Ensembl
Nephrogenic mesenchyme morphogenesis Source: Ensembl
Neural fold elevation formation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Pericardium morphogenesis Source: Ensembl
Pharyngeal system development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
Positive regulation of epithelial to mesenchymal transition Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of branching involved in prostate gland morphogenesis Source: Ensembl
Regulation of phosphorylation Source: Ensembl
Response to estradiol Source: Ensembl
Response to peptide hormone Source: Ensembl
Response to vitamin D Source: Ensembl
Ureteric bud development Source: Ensembl
Cellular Location
Extracellular space; Collagen-containing extracellular matrix; Vesicle

Aluganti Narasimhulu, C., & Singla, D. K. (2020). The role of bone morphogenetic protein 7 (BMP-7) in inflammation in heart diseases. Cells, 9(2), 280.

Saburi, E., Atabati, H., Kabiri, L., Behdari, A., Azizi, M., Ardeshirylajimi, A., ... & Omrani, M. D. (2019). Bone morphogenetic protein‐7 incorporated polycaprolactone scaffold has a great potential to improve survival and proliferation rate of the human embryonic kidney cells. Journal of cellular biochemistry, 120(6), 9859-9868.

Sun, N., Chen, Y., Yu, F., Zhixin, F., Lin, J., Sun, B., ... & Wu, B. (2019). Monocrotaline pyrrole enhanced bone morphogenetic protein 7 signaling transduced by alternative activin A receptor type 2A in pulmonary arterial smooth muscle cells. European journal of pharmacology, 863, 172679.

Zou, G. L., Zuo, S., Lu, S., Hu, R. H., Lu, Y. Y., Yang, J., ... & Li, H. Y. (2019). Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway. World journal of gastroenterology, 25(30), 4222.

Chen, F., Bi, D., Cheng, C., Ma, S., Liu, Y., & Cheng, K. (2019). Bone morphogenetic protein 7 enhances the osteogenic differentiation of human dermal-derived CD105+ fibroblast cells through the Smad and MAPK pathways. International journal of molecular medicine, 43(1), 37-46.

Lee, H., Min, S. K., Song, Y., Park, Y. H., & Park, J. B. (2019). Bone morphogenetic protein‑7 upregulates genes associated with osteoblast differentiation, including collagen I, Sp7 and IBSP in gingiva‑derived stem cells. Experimental and therapeutic medicine, 18(4), 2867-2876.

Shoulders, H., Garner, K. H., & Singla, D. K. (2019). Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis. Translational Research, 203, 1-14.

Reible, B., Schmidmaier, G., Moghaddam, A., & Westhauser, F. (2018). Insulin-like growth factor-1 as a possible alternative to bone morphogenetic protein-7 to induce osteogenic differentiation of human mesenchymal stem cells in vitro. International Journal of Molecular Sciences, 19(6), 1674.

Kowtharapu, B. S., Prakasam, R. K., Murín, R., Koczan, D., Stahnke, T., Wree, A., ... & Stachs, O. (2018). Role of bone morphogenetic protein 7 (BMP7) in the modulation of corneal stromal and epithelial cell functions. International journal of molecular sciences, 19(5), 1415.

Chattopadhyay, T., Singh, R. R., Gupta, S., & Surolia, A. (2017). Bone morphogenetic protein‐7 (BMP‐7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway. Biofactors, 43(2), 195-209.

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For research use only. Not intended for any clinical use.

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