BMP7

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

Full Name

Bone Morphogenetic Protein 7

Biological Process

Allantois development Source: Ensembl
Axon guidance Source: Ensembl
BMP signaling pathway Source: Ensembl
Branching involved in salivary gland morphogenesis Source: Ensembl
Branching morphogenesis of an epithelial tube Source: Ensembl
Cardiac muscle tissue development Source: Ensembl
Cardiac septum morphogenesis Source: Ensembl
Chorio-allantoic fusion Source: Ensembl
Embryonic camera-type eye morphogenesis Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Embryonic pattern specification Source: Ensembl
Embryonic skeletal joint morphogenesis Source: Ensembl
Endocardial cushion formation Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Heart trabecula morphogenesis Source: Ensembl
Hindbrain development Source: Ensembl
Mesoderm formation Source: Ensembl
Metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
Metanephric mesenchyme morphogenesis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of prostatic bud formation Source: Ensembl
Nephrogenic mesenchyme morphogenesis Source: Ensembl
Neural fold elevation formation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Pericardium morphogenesis Source: Ensembl
Pharyngeal system development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
Positive regulation of epithelial to mesenchymal transition Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of branching involved in prostate gland morphogenesis Source: Ensembl
Regulation of phosphorylation Source: Ensembl
Response to estradiol Source: Ensembl
Response to peptide hormone Source: Ensembl
Response to vitamin D Source: Ensembl
Ureteric bud development Source: Ensembl

Cellular Location

Extracellular space; Collagen-containing extracellular matrix; Vesicle