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Mouse Anti-BMP7 Recombinant Antibody (CBYY-1657) (CBMAB-2006-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1657
Antibody Isotype
IgG2
Application
WB, P, N

Basic Information

Immunogen
Human recombinant BMP-7.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000
IHC-P1:20-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bone Morphogenetic Protein 7
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in Bovinene, kidney and brown adipose tissue development. Additionally, this protein induces ectopic Bovinene formation and may promote fracture healing in human patients.
Entrez Gene ID
655
UniProt ID
P18075
Alternative Names
Bovinene Morphogenetic Protein 7; Osteogenic Protein 1; OP-1; Eptotermin Alfa; BMP-7; OP1;
Biological Process
Allantois development Source: Ensembl
Axon guidance Source: Ensembl
BMP signaling pathway Source: Ensembl
Branching involved in salivary gland morphogenesis Source: Ensembl
Branching morphogenesis of an epithelial tube Source: Ensembl
Cardiac muscle tissue development Source: Ensembl
Cardiac septum morphogenesis Source: Ensembl
Chorio-allantoic fusion Source: Ensembl
Embryonic camera-type eye morphogenesis Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Embryonic pattern specification Source: Ensembl
Embryonic skeletal joint morphogenesis Source: Ensembl
Endocardial cushion formation Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Heart trabecula morphogenesis Source: Ensembl
Hindbrain development Source: Ensembl
Mesoderm formation Source: Ensembl
Metanephric mesenchymal cell proliferation involved in metanephros development Source: Ensembl
Metanephric mesenchyme morphogenesis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of prostatic bud formation Source: Ensembl
Nephrogenic mesenchyme morphogenesis Source: Ensembl
Neural fold elevation formation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Pericardium morphogenesis Source: Ensembl
Pharyngeal system development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
Positive regulation of epithelial to mesenchymal transition Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of branching involved in prostate gland morphogenesis Source: Ensembl
Regulation of phosphorylation Source: Ensembl
Response to estradiol Source: Ensembl
Response to peptide hormone Source: Ensembl
Response to vitamin D Source: Ensembl
Ureteric bud development Source: Ensembl
Cellular Location
Extracellular space; Collagen-containing extracellular matrix; Vesicle
More Infomation

Aluganti Narasimhulu, C., & Singla, D. K. (2020). The role of bone morphogenetic protein 7 (BMP-7) in inflammation in heart diseases. Cells, 9(2), 280.

Saburi, E., Atabati, H., Kabiri, L., Behdari, A., Azizi, M., Ardeshirylajimi, A., ... & Omrani, M. D. (2019). Bone morphogenetic protein‐7 incorporated polycaprolactone scaffold has a great potential to improve survival and proliferation rate of the human embryonic kidney cells. Journal of cellular biochemistry, 120(6), 9859-9868.

Sun, N., Chen, Y., Yu, F., Zhixin, F., Lin, J., Sun, B., ... & Wu, B. (2019). Monocrotaline pyrrole enhanced bone morphogenetic protein 7 signaling transduced by alternative activin A receptor type 2A in pulmonary arterial smooth muscle cells. European journal of pharmacology, 863, 172679.

Zou, G. L., Zuo, S., Lu, S., Hu, R. H., Lu, Y. Y., Yang, J., ... & Li, H. Y. (2019). Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway. World journal of gastroenterology, 25(30), 4222.

Chen, F., Bi, D., Cheng, C., Ma, S., Liu, Y., & Cheng, K. (2019). Bone morphogenetic protein 7 enhances the osteogenic differentiation of human dermal-derived CD105+ fibroblast cells through the Smad and MAPK pathways. International journal of molecular medicine, 43(1), 37-46.

Lee, H., Min, S. K., Song, Y., Park, Y. H., & Park, J. B. (2019). Bone morphogenetic protein‑7 upregulates genes associated with osteoblast differentiation, including collagen I, Sp7 and IBSP in gingiva‑derived stem cells. Experimental and therapeutic medicine, 18(4), 2867-2876.

Shoulders, H., Garner, K. H., & Singla, D. K. (2019). Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis. Translational Research, 203, 1-14.

Reible, B., Schmidmaier, G., Moghaddam, A., & Westhauser, F. (2018). Insulin-like growth factor-1 as a possible alternative to bone morphogenetic protein-7 to induce osteogenic differentiation of human mesenchymal stem cells in vitro. International Journal of Molecular Sciences, 19(6), 1674.

Kowtharapu, B. S., Prakasam, R. K., Murín, R., Koczan, D., Stahnke, T., Wree, A., ... & Stachs, O. (2018). Role of bone morphogenetic protein 7 (BMP7) in the modulation of corneal stromal and epithelial cell functions. International journal of molecular sciences, 19(5), 1415.

Chattopadhyay, T., Singh, R. R., Gupta, S., & Surolia, A. (2017). Bone morphogenetic protein‐7 (BMP‐7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway. Biofactors, 43(2), 195-209.

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For research use only. Not intended for any clinical use.

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