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Rat Anti-BMPER Recombinant Antibody (349920) (CBMAB-C5551-LY)

This product is antibody recognizes BMPER. The antibody 349920 immunoassay techniques such as: WB.
See all BMPER antibodies
Published Data
Fig.1 Extracellular Bmper is actively internalized by selective cell types.
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Fig.2 Bmper accumulated in large punctuate vesicles in MECs treated with Bmper and chased with media containing chloroquine.
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Fig.3 Endocytic targeting of Bmper.
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Fig.4 Bmp4 and Bmper are reciprocally regulated by internalization.
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Fig.5 Bmper and Bmp4 internalize through a clathrin-dependent mechanism.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
349920
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Crossveinless-2/CV-2, Val34-Arg685, Accession # AAH66153
Specificity
Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BMP Binding Endothelial Regulator
Introduction
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
Entrez Gene ID
73230
UniProt ID
Q8CJ69
Function
Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
Biological Process
Blood vessel development Source: GO_Central
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
Endothelial cell activation Source: BHF-UCL
Inner ear development Source: Ensembl
Negative regulation of BMP signaling pathway Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of sprouting angiogenesis Source: BHF-UCL
Regulation of angiogenesis Source: GO_Central
Regulation of endothelial cell migration Source: BHF-UCL
Regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Ureteric bud development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Diaphanospondylodysostosis (DSD): A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.

Mao, H., Li, L., Fan, Q., Angelini, A., Saha, P. K., Wu, H., ... & Pi, X. (2021). Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nature communications, 12(1), 1-10.

Lockhart-Cairns, M. P., Lim, K. T. W., Zuk, A., Godwin, A. R., Cain, S. A., Sengle, G., & Baldock, C. (2019). Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER. Matrix Biology, 77, 73-86.

Osmanagic‐Myers, S., & Rezniczek, G. A. (2018). Arteriovenous specification: BMPER and TWSG 1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling. The FEBS journal, 285(8), 1399-1402.

Xiao, F., Wang, C., Wang, C., Gao, Y., Zhang, X., & Chen, X. (2018). BMPER enhances bone formation by promoting the osteogenesis-angiogenesis coupling process in mesenchymal stem cells. Cellular Physiology and Biochemistry, 45(5), 1927-1939.

Lockyer, P., Mao, H., Fan, Q., Li, L., Yu-Lee, L. Y., Eissa, N. T., ... & Pi, X. (2017). LRP1-dependent BMPER signaling regulates lipopolysaccharide-induced vascular inflammation. Arteriosclerosis, thrombosis, and vascular biology, 37(8), 1524-1535.

Hasebe, T., Tanaka, H., Sawada, K., Nakajima, S., Ohtake, T., Fujiya, M., & Kohgo, Y. (2017). Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model. Journal of gastroenterology, 52(3), 341-351.

Helbing, T., Wiltgen, G., Hornstein, A., Brauers, E. Z., Arnold, L., Bauer, A., ... & Moser, M. (2017). Bone morphogenetic protein-modulator BMPER regulates endothelial barrier function. Inflammation, 40(2), 442-453.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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