Rat Anti-BMPER Recombinant Antibody (CBXC-1139) (CBMAB-C5539-CQ)

Name: Rat Anti-BMPER Recombinant Antibody (CBXC-1139)
SKU: CBMAB-C5539-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXC-1139

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Crossveinless‑2/CV‑2 Val34-Arg685.

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BMP Binding Endothelial Regulator

Introduction

This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis.

Entrez Gene ID

168667

UniProt ID

Q8N8U9

Alternative Names

BMP Binding Endothelial Regulator; Bone Morphogenetic Protein-Binding Endothelial Cell Precursor-Derived Regulator; HCV2; BMP-Binding Endothelial Regulator Precursor Protein; BMP-Binding Endothelial Regulator Protein; Protein Crossveinless-2; Crossveinless-2;

Function

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.

Biological Process

Blood vessel development Source: GO_Central
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
Endothelial cell activation Source: BHF-UCL
Inner ear development Source: Ensembl
Negative regulation of BMP signaling pathway Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of sprouting angiogenesis Source: BHF-UCL
Regulation of angiogenesis Source: GO_Central
Regulation of endothelial cell migration Source: BHF-UCL
Regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Ureteric bud development Source: Ensembl

Cellular Location

Secreted

Involvement in disease

Diaphanospondylodysostosis (DSD): A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.

Mao, H., Li, L., Fan, Q., Angelini, A., Saha, P. K., Wu, H., ... & Pi, X. (2021). Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nature communications, 12(1), 1-10.

Lockhart-Cairns, M. P., Lim, K. T. W., Zuk, A., Godwin, A. R., Cain, S. A., Sengle, G., & Baldock, C. (2019). Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER. Matrix Biology, 77, 73-86.

Osmanagic‐Myers, S., & Rezniczek, G. A. (2018). Arteriovenous specification: BMPER and TWSG 1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling. The FEBS journal, 285(8), 1399-1402.

Xiao, F., Wang, C., Wang, C., Gao, Y., Zhang, X., & Chen, X. (2018). BMPER enhances bone formation by promoting the osteogenesis-angiogenesis coupling process in mesenchymal stem cells. Cellular Physiology and Biochemistry, 45(5), 1927-1939.

Lockyer, P., Mao, H., Fan, Q., Li, L., Yu-Lee, L. Y., Eissa, N. T., ... & Pi, X. (2017). LRP1-dependent BMPER signaling regulates lipopolysaccharide-induced vascular inflammation. Arteriosclerosis, thrombosis, and vascular biology, 37(8), 1524-1535.

Hasebe, T., Tanaka, H., Sawada, K., Nakajima, S., Ohtake, T., Fujiya, M., & Kohgo, Y. (2017). Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model. Journal of gastroenterology, 52(3), 341-351.

Helbing, T., Wiltgen, G., Hornstein, A., Brauers, E. Z., Arnold, L., Bauer, A., ... & Moser, M. (2017). Bone morphogenetic protein-modulator BMPER regulates endothelial barrier function. Inflammation, 40(2), 442-453.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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