Human BMPER ELISA Kit (V2LY-0626-LY2633)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.029 ng/mL
Detection Range
0.05-10 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
76.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
BMP Binding Endothelial Regulator
Function
Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
Biological Process
Blood vessel development Source: GO_Central
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
Endothelial cell activation Source: BHF-UCL
Inner ear development Source: Ensembl
Negative regulation of BMP signaling pathway Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of sprouting angiogenesis Source: BHF-UCL
Regulation of angiogenesis Source: GO_Central
Regulation of endothelial cell migration Source: BHF-UCL
Regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Ureteric bud development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Diaphanospondylodysostosis (DSD): A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.

Mao, H., Li, L., Fan, Q., Angelini, A., Saha, P. K., Wu, H., ... & Pi, X. (2021). Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nature communications, 12(1), 1-10.

Lockhart-Cairns, M. P., Lim, K. T. W., Zuk, A., Godwin, A. R., Cain, S. A., Sengle, G., & Baldock, C. (2019). Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER. Matrix Biology, 77, 73-86.

Osmanagic‐Myers, S., & Rezniczek, G. A. (2018). Arteriovenous specification: BMPER and TWSG 1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling. The FEBS journal, 285(8), 1399-1402.

Xiao, F., Wang, C., Wang, C., Gao, Y., Zhang, X., & Chen, X. (2018). BMPER enhances bone formation by promoting the osteogenesis-angiogenesis coupling process in mesenchymal stem cells. Cellular Physiology and Biochemistry, 45(5), 1927-1939.

Lockyer, P., Mao, H., Fan, Q., Li, L., Yu-Lee, L. Y., Eissa, N. T., ... & Pi, X. (2017). LRP1-dependent BMPER signaling regulates lipopolysaccharide-induced vascular inflammation. Arteriosclerosis, thrombosis, and vascular biology, 37(8), 1524-1535.

Hasebe, T., Tanaka, H., Sawada, K., Nakajima, S., Ohtake, T., Fujiya, M., & Kohgo, Y. (2017). Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model. Journal of gastroenterology, 52(3), 341-351.

Helbing, T., Wiltgen, G., Hornstein, A., Brauers, E. Z., Arnold, L., Bauer, A., ... & Moser, M. (2017). Bone morphogenetic protein-modulator BMPER regulates endothelial barrier function. Inflammation, 40(2), 442-453.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rat Anti-BMPER Recombinant Antibody (CBXC-1139) (CAT#: CBMAB-C5539-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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