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Mouse Anti-BRK1 Recombinant Antibody (CBYC-P030) (CBMAB-P0117-YC)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBYC-P030
Application
E, WB
Immunogen
Recombinant protein corresponding to full length Probable protein BRICK1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
BRICK1, SCAR/WAVE Actin Nucleating Complex Subunit
Introduction
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Entrez Gene ID
55845
UniProt ID
Q8WUW1
Alternative Names
C3orf10; HSPC300; MDS027; hHBrk1
Function
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Biological Process
Actin filament organization Source: InterPro
Cell motility Source: GO_Central
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
In utero embryonic development Source: Ensembl
Positive regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of lamellipodium assembly Source: ARUK-UCL
Positive regulation of protein-containing complex assembly Source: UniProtKB
Rac protein signal transduction Source: UniProtKB
Regulation of actin polymerization or depolymerization Source: GO_Central
Vascular endothelial growth factor receptor signaling pathway Source: Reactome
Cellular Location
Cytoskeleton

Lim, S. P., Ioannou, N., Ramsay, A. G., Darling, D., Gäken, J., & Mufti, G. J. (2018). miR‐181c‐BRK1 axis plays a key role in actin cytoskeleton‐dependent T cell function. Journal of leukocyte biology, 103(5), 855-866.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Mouse Anti-BRK1 Recombinant Antibody (CBLC009-LY) (CAT#: CBMAB-C9495-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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