Mouse Anti-BRMS1 Recombinant Antibody (CBYY-0813) (CBMAB-0816-YY)

Name: Mouse Anti-BRMS1 Recombinant Antibody (CBYY-0813)
SKU: CBMAB-0816-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-0813

Application

E, WB

Immunogen

BRMS1 (AAH09834, 1 a.a. ~ 246 a.a) full-length recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 111-160

More Infomation

Target

Full Name

Breast Cancer Metastasis Suppressor 1

Introduction

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the Mousein3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforMouse.

Entrez Gene ID

25855

UniProt ID

Q9HCU9

Alternative Names

Breast Cancer Metastasis Suppressor 1;

Function

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Biological Process

Apoptotic process Source: UniProtKB-KW
Histone deacetylation Source: GO_Central
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of anoikis Source: UniProtKB
Positive regulation of protein deacetylation Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm. Predominantly nuclear.

PTM

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.

Zimmermann, R. C., & Welch, D. R. (2020). BRMS1: a multifunctional signaling molecule in metastasis. Cancer and Metastasis Reviews, 1-14.

Qiu, R., Shi, H., Wang, S., Leng, S., Liu, R., Zheng, Y., ... & Yang, Y. (2018). BRMS1 coordinates with LSD1 and suppresses breast cancer cell metastasis. American journal of cancer research, 8(10), 2030.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-BRMS1 Recombinant Antibody (EG413) (CAT#: CBMAB-EN471-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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