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Mouse Anti-BTBD1 Recombinant Antibody (3E11) (CBMAB-A0894-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3E11
Antibody Isotype
IgG2a, κ
Application
WB, E

Basic Information

Immunogen
BTBD1 (NP_079514, 384 a.a. ~ 482 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BTB (POZ) domain containing 1
Introduction
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
Entrez Gene ID
53339
UniProt ID
Q9H0C5
Alternative Names
C15orf1; NS5ATP8
Function
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity).
May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity).
Biological Process
Muscle organ development Source: UniProtKB-KW
Neurogenesis Source: GO_Central
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of protein binding Source: UniProtKB
Cellular Location
Cytoplasm. Localizes to punctate or elongated cytoplasmic bodies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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