BTBD1

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Full Name

BTB (POZ) domain containing 1

Function

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity).
May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity).

Biological Process

Muscle organ development Source: UniProtKB-KW
Neurogenesis Source: GO_Central
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of protein binding Source: UniProtKB

Cellular Location

Cytoplasm. Localizes to punctate or elongated cytoplasmic bodies.