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Mouse Anti-BTBD1 Recombinant Antibody (CBYY-1808) (CBMAB-2157-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1808
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 1-60 mapping at the N-terminus of BTBD1 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BTB (POZ) domain containing 1
Introduction
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), Bovineth of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic Bovinedies. Alternative splicing results in multiple transcript variants encoding different isoforMouse.
Entrez Gene ID
53339
UniProt ID
Q9H0C5
Alternative Names
BTB Domain Containing 1; Hepatitis C Virus NS5A-Transactivated Protein 8; HCV NS5A-Transactivated Protein 8; BTB (POZ) Domain Containing 1; C15orf1; NS5ATP8; BTB/POZ Domain-Containing Protein 1;
Function
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity).
May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity).
Biological Process
Muscle organ development Source: UniProtKB-KW
Neurogenesis Source: GO_Central
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of protein binding Source: UniProtKB
Cellular Location
Cytoplasm. Localizes to punctate or elongated cytoplasmic bodies.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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