Mouse Anti-C7 Recombinant Antibody (15D1) (CBMAB-C9567-LY)
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Target
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Basic Information
Host Animal
Mouse
Clone
15D1
Application
WB, IC, IH, FC
Immunogen
Recombinant protein within Human Complement C7 aa 498-641 / 843.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
| Application | Note |
| WB | 1:500-1:2,000 |
| IF(ICC) | 1:50-1:200 |
| FC | 1:50-1:100 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Format
Liquid
Buffer
PBS, pH7.4, 0.2% BSA, 50% Glycerol
Preservative
0.05% sodium azide
Concentration
2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation
Target
Full Name
complement C7
Introduction
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.
Entrez Gene ID
UniProt ID
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
Biological Process
Cellular sodium ion homeostasis Source: Ensembl
Complement activation Source: Reactome
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Regulation of complement activation Source: Reactome
Complement activation Source: Reactome
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 7 deficiency (C7D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
C7 has 28 disulfide bridges.
C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
For research use only. Not intended for any clinical use.
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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