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Mouse Anti-C7 Recombinant Antibody (15D1) (CBMAB-C9567-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
15D1
Antibody Isotype
IgG1
Application
WB, IC, IH, FC

Basic Information

Immunogen
Recombinant protein within Human Complement C7 aa 498-641 / 843.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IF(ICC)1:50-1:200
FC1:50-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 0.2% BSA, 50% Glycerol
Preservative
0.05% sodium azide
Concentration
2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
complement C7
Introduction
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.
Entrez Gene ID
730
UniProt ID
P10643
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
Biological Process
Cellular sodium ion homeostasis Source: Ensembl
Complement activation Source: Reactome
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 7 deficiency (C7D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
C7 has 28 disulfide bridges.
C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
More Infomation

Guo, H., Yan, Z., Hu, Y., Huang, X., & Pan, C. (2021). Complement C7 is Specifically Expressed in Mesangial Cells and is a Potential Diagnostic Biomarker for Diabetic Nephropathy and is Regulated by miR-494-3p and miR-574-5p. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 14, 3077.

Lukassen, M. V., Franc, V., Hevler, J. F., & Heck, A. J. (2021). Similarities and differences in the structures and proteoform profiles of the complement proteins C6 and C7. Proteomics, 2000310.

He, J., Fu, J., & Fan, D. (2021). The complement C7 variant rs3792646 is associated with amyotrophic lateral sclerosis in a Han Chinese population. Neurobiology of Aging, 99, 103-e1.

Kageyama, M., Hagiya, H., Ueda, Y., Ohtani, K., Fukumori, Y., Inoue, N., ... & Rakugi, H. (2021). Disseminated gonococcal infection in a Japanese man with complement 7 deficiency with compound heterozygous variants: A case report. Medicine, 100(13).

Aarsetoey, R., Ueland, T., Aukrust, P., Michelsen, A. E., Ponitz, V., Brugger-Andersen, T., ... & Nilsen, D. W. T. (2020). Complement component-7 is a long-term predictor of all-cause mortality in chest-pain patients with suspected acute coronary syndrome. European Heart Journal, 41(Supplement_2), ehaa946-1610.

Zhang, D. F., Fan, Y., Xu, M., Wang, G., Wang, D., Li, J., ... & Yao, Y. G. (2019). Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese. National science review, 6(2), 257-274.

Sircar, M., Rosales, I. A., Selig, M. K., Xu, D., Zsengeller, Z. K., Stillman, I. E., ... & Thadhani, R. I. (2018). Complement 7 is up-regulated in human early diabetic kidney disease. The American journal of pathology, 188(10), 2147-2154.

Shao, T., Qin, C., Duan, H., Yuan, D., Wen, Z., Wang, J., & Ge, F. (2018). Effects of feeding time on complement component C7 expression in Pelteobagrus vachellii subject to bacterial challenge. Journal of Oceanology and Limnology, 36(6), 2358-2367.

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For research use only. Not intended for any clinical use.

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