Human Recombinant C7 protein, hFc Tag (V2LY-0526-LY3332)

Name: Human Recombinant C7 protein, hFc Tag
SKU: V2LY-0526-LY3332
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant C7 protein, hFc Tag consist of Amino Acid: 1-843 and predicts a molecular mass of 118 kDa.

Molecule Mass

118 kDa

Sequence

Amino Acid: 1-843

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

complement C7

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

Biological Process

Cellular sodium ion homeostasis Source: Ensembl
Complement activation Source: Reactome
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Regulation of complement activation Source: Reactome

Cellular Location

Secreted

Involvement in disease

Complement component 7 deficiency (C7D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

PTM

C7 has 28 disulfide bridges.
C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

Guo, H., Yan, Z., Hu, Y., Huang, X., & Pan, C. (2021). Complement C7 is Specifically Expressed in Mesangial Cells and is a Potential Diagnostic Biomarker for Diabetic Nephropathy and is Regulated by miR-494-3p and miR-574-5p. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 14, 3077.

Lukassen, M. V., Franc, V., Hevler, J. F., & Heck, A. J. (2021). Similarities and differences in the structures and proteoform profiles of the complement proteins C6 and C7. Proteomics, 2000310.

He, J., Fu, J., & Fan, D. (2021). The complement C7 variant rs3792646 is associated with amyotrophic lateral sclerosis in a Han Chinese population. Neurobiology of Aging, 99, 103-e1.

Kageyama, M., Hagiya, H., Ueda, Y., Ohtani, K., Fukumori, Y., Inoue, N., ... & Rakugi, H. (2021). Disseminated gonococcal infection in a Japanese man with complement 7 deficiency with compound heterozygous variants: A case report. Medicine, 100(13).

Aarsetoey, R., Ueland, T., Aukrust, P., Michelsen, A. E., Ponitz, V., Brugger-Andersen, T., ... & Nilsen, D. W. T. (2020). Complement component-7 is a long-term predictor of all-cause mortality in chest-pain patients with suspected acute coronary syndrome. European Heart Journal, 41(Supplement_2), ehaa946-1610.

Zhang, D. F., Fan, Y., Xu, M., Wang, G., Wang, D., Li, J., ... & Yao, Y. G. (2019). Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese. National science review, 6(2), 257-274.

Sircar, M., Rosales, I. A., Selig, M. K., Xu, D., Zsengeller, Z. K., Stillman, I. E., ... & Thadhani, R. I. (2018). Complement 7 is up-regulated in human early diabetic kidney disease. The American journal of pathology, 188(10), 2147-2154.

Shao, T., Qin, C., Duan, H., Yuan, D., Wen, Z., Wang, J., & Ge, F. (2018). Effects of feeding time on complement component C7 expression in Pelteobagrus vachellii subject to bacterial challenge. Journal of Oceanology and Limnology, 36(6), 2358-2367.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant C7 protein, His Tag (CAT#: V2LY-0526-LY3333)

Mouse Recombinant C7 protein, His Tag (CAT#: V2LY-0526-LY8146)

Human C7 ELISA Kit (CAT#: V2LY-0626-LY748)

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Mouse Recombinant C7 protein, His Tag (CAT#: V2LY-0526-LY8146)

Human Recombinant C7 protein, His Tag (CAT#: V2LY-0526-LY3333)

Human C7 ELISA Kit (CAT#: V2LY-0626-LY748)

Rabbit Anti-C7 Recombinant Antibody (009) (CAT#: CBMAB-C1552-LY)

Mouse Anti-C7 Recombinant Antibody (15D1) (CAT#: CBMAB-C9567-LY)

Rabbit Anti-C7 Recombinant Antibody (CBFYC-0671) (CAT#: CBMAB-C0725-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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