C7

This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.
Full Name
complement C7
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
Biological Process
Cellular sodium ion homeostasis Source: Ensembl
Complement activation Source: Reactome
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 7 deficiency (C7D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
C7 has 28 disulfide bridges.
C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
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Anti-C7 antibodies

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Rabbit Anti-C7 Recombinant Antibody (009) (CBMAB-C1552-LY)

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Target: C7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 009
Application*: E
Datasheet SDS

Human C7 ELISA Kit (V2LY-0626-LY748)

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Target: C7
Sensitivity: 1.79 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Recombinant C7 protein, His Tag (V2LY-0526-LY8146)

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Target: C7
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 23-845
Tag: His Tag
Datasheet SDS

Human Recombinant C7 protein, His Tag (V2LY-0526-LY3333)

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Target: C7
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-843
Tag: His Tag
Datasheet SDS

Human Recombinant C7 protein, hFc Tag (V2LY-0526-LY3332)

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Target: C7
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-843
Tag: hFc Tag
Datasheet SDS

Mouse Anti-C7 Recombinant Antibody (15D1) (CBMAB-C9567-LY)

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Target: C7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 15D1
Application*: WB, IC, IH, FC
Datasheet SDS

Rabbit Anti-C7 Recombinant Antibody (CBFYC-0671) (CBMAB-C0725-FY)

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Target: C7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0671
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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