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Mouse Anti-CACNA2D1 Recombinant Antibody (20A) (CBMAB-1264-CN)

This product is a mouse antibody that recognizes CACNA2D1 of rabbit. The antibody 20A can be used for immunoassay techniques such as: FC, ICC, IF, IHC-Fr, IHC-P, IP, WB.
See all CACNA2D1 antibodies
Published Data
Fig.1 Cocaine self-administration upregulates is increased after co- caine self-administration.
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Fig.2 LC3 expression was analyzed by Western blot in the hemi-cord contralateral.
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Fig.3 Dorsal spinal cord Cavα2δ1 levels were down-regulated significantly from both sides of rats similarly injected with Cavα2δ1-AAV 10 days ago compared with that in rats injected with the control AAV.
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Fig.4 TSP4 ablation blocked SNL-induced excitatory synaptogenesis.
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Summary

Host Animal
Mouse
Specificity
Rabbit, Mouse, Rat, Chicken, Guinea pig, Human, Pig
Clone
20A
Antibody Isotype
IgG2a
Application
FC, ICC, IF, IHC-Fr, IHC-P, IP, WB

Basic Information

Immunogen
Full length native protein (purified) corresponding to Rabbit Calcium channel L type DHPR alpha 2 subunit.
Specificity
Rabbit, Mouse, Rat, Chicken, Guinea pig, Human, Pig
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CALCIUM VOLTAGE-GATED CHANNEL AUXILIARY SUBUNIT ALPHA2DELTA 1
Introduction
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. This protein plays an important role in excitation-contraction coupling.
Entrez Gene ID
Human781
Mouse12293
Rat25399
Pig397377
Guinea pig100728887
Chicken768444
UniProt ID
HumanP54289
MouseO08532
RatP54290
PigQ002C1
Guinea pigH0VKR3
ChickenE1BST5
Alternative Names
voltage-dependent calcium channel subunit alpha-2/delta-1; calcium channel, voltage-dependent, alpha 2/delta subunit 1; dihydropryridine-sensitive calcium channel alpha-2 subunit; voltage-gated calcium channel subunit alpha-2/delta-1
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Biological Process
Calcium ion import across plasma membrane Source: BHF-UCL
Calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
Calcium ion transport Source: UniProtKB
Calcium ion transport into cytosol Source: BHF-UCL
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Membrane depolarization during bundle of His cell action potential Source: BHF-UCL
Positive regulation of high voltage-gated calcium channel activity Source: BHF-UCL
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: ARUK-UCL
Regulation of calcium ion transport Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of membrane repolarization during action potential Source: BHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarization Source: BHF-UCL
Cellular Location
Membrane
Topology
Extracellular: 25-1073 aa
Helical: 1074-1094 aa
Cytoplasmic: 1095-1103 aa
PTM
Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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