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Mouse Anti-CACNA2D1 Recombinant Antibody (CBFYC-0720) (CBMAB-C0775-FY)

This product is mouse antibody that recognizes CACNA2D1. The antibody CBFYC-0720 can be used for immunoassay techniques such as: FC, IF, IHC, IHC-Fr, IHC-P, IP, WB.
See all CACNA2D1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-0720
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, E, P

Basic Information

Immunogen
Amino acids 25-171 mapping near the N-terminus of Cacna2d1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CALCIUM VOLTAGE-GATED CHANNEL AUXILIARY SUBUNIT ALPHA2DELTA 1
Introduction
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion.
Entrez Gene ID
Human781
Mouse12293
Rat25399
Pig397377
Guinea pig100728887
UniProt ID
HumanP54289
MouseO08532
RatP54290
PigQ002C1
Guinea pigH0VKR3
Alternative Names
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Biological Process
Calcium ion import across plasma membrane Source: BHF-UCL
Calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
Calcium ion transport Source: UniProtKB
Calcium ion transport into cytosol Source: BHF-UCL
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Membrane depolarization during bundle of His cell action potential Source: BHF-UCL
Positive regulation of high voltage-gated calcium channel activity Source: BHF-UCL
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: ARUK-UCL
Regulation of calcium ion transport Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of membrane repolarization during action potential Source: BHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarization Source: BHF-UCL
Cellular Location
Membrane
Topology
Extracellular: 25-1073 aa
Helical: 1074-1094 aa
Cytoplasmic: 1095-1103 aa
PTM
Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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