Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CACYBP Recombinant Antibody (CBT249) (V2LY-0625-LY3667)


See all CACYBP antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT249
Antibody Isotype
IgG
Application
WB, IHC-P, IF, ELISA

Basic Information

Immunogen
Purified recombinant fragment of Calcyclin expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
IHC1:200-1:1,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calcyclin Binding Protein
Entrez Gene ID
27101
UniProt ID
Q9HB71
Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Biological Process
Aging Source: Ensembl
Cardiac muscle cell differentiation Source: Ensembl
Cellular response to calcium ion Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Heart development Source: GO_Central
Negative regulation of cell death Source: Ensembl
Positive regulation of DNA replication Source: Ensembl
Response to growth hormone Source: Ensembl
Cellular Location
Nucleus; Cytoplasm. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
PTM
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
More Infomation

Zheng, H., & Chen, C. (2021). Downregulation of CacyBP by CRISPR/dCas9-KRAB Prevents Bladder Cancer Progression. Frontiers in Molecular Biosciences, 8, 557.

Xu, Y. J., Hu, Y. M., Qin, C., Wang, F., Cao, W., Yu, Y. W., ... & He, J. (2021). CacyBP promotes the proliferation and invasion of non-small cell lung cancer. Zhonghua Zhong liu za zhi [Chinese Journal of Oncology], 43(9), 924-931.

Lian, Y. F., Huang, Y. L., Zhang, Y. J., Chen, D. M., Wang, J. L., Wei, H., ... & Huang, Y. H. (2019). CACYBP enhances cytoplasmic retention of P27Kip1 to promote hepatocellular carcinoma progression in the absence of RNF41 mediated degradation. Theranostics, 9(26), 8392.

Kasacka, I., Piotrowska, Ż., Weresa, J., & Filipek, A. (2018). Comparative evaluation of CacyBP/SIP protein, β-catenin, and immunoproteasome subunit LMP7 in the heart of rats with hypertension of different etiology. Experimental Biology and Medicine, 243(15-16), 1199-1206.

Feng, S., Zhou, Q., Yang, B., Li, Q., Liu, A., Zhao, Y., ... & Zhai, H. (2018). The effect of S100A6 on nuclear translocation of CacyBP/SIP in colon cancer cells. Plos one, 13(3), e0192208.

Yan, S., Li, A., & Liu, Y. (2018). CacyBP/SIP inhibits the migration and invasion behaviors of glioblastoma cells through activating Siah1 mediated ubiquitination and degradation of cytoplasmic p27. Cell biology international, 42(2), 216-226.

Topolska-Woś, A. M., Rosińska, S., & Filipek, A. (2017). MAP kinase p38 is a novel target of CacyBP/SIP phosphatase. Amino Acids, 49(6), 1069-1076.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CACYBP Recombinant Antibody (CBT249)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry