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CACYBP

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Calcyclin Binding Protein
Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Biological Process
Aging Source: Ensembl
Cardiac muscle cell differentiation Source: Ensembl
Cellular response to calcium ion Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Heart development Source: GO_Central
Negative regulation of cell death Source: Ensembl
Positive regulation of DNA replication Source: Ensembl
Response to growth hormone Source: Ensembl
Cellular Location
Nucleus; Cytoplasm. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
PTM
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.

Anti-CACYBP antibodies

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Mouse Anti-CACYBP Recombinant Antibody (CBFYC-0725) (CBMAB-C0780-FY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0725
Application*: DB, F, IC, WB

Mouse Anti-CACYBP Recombinant Antibody (CBXC-2203) (CBMAB-C0204-CQ)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2203
Application*: WB, E

Mouse Anti-CACYBP Recombinant Antibody (CBYY-C0863) (CBMAB-C2299-YY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0863
Application*: E, WB, IH

Mouse Anti-CACYBP Recombinant Antibody (CBYY-C0864) (CBMAB-C2300-YY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-C0864
Application*: F, IC, WB

Rabbit Anti-CACYBP Recombinant Antibody (D43G11) (CBMAB-CP0061-LY)

Datasheet SDS
Target: CACYBP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D43G11
Application*: WB, P, F

Mouse Anti-CACYBP Recombinant Antibody (CBXC-0041) (CBMAB-C5753-CQ)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0041
Application*: E, WB

Mouse Anti-CACYBP Recombinant Antibody (CBXS-4266) (CBMAB-S1516-CQ)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4266
Application*: WB, DB

Mouse Anti-CACYBP Recombinant Antibody (CBXS-1036) (CBMAB-S3929-CQ)

Datasheet SDS
Target: CACYBP
Host: Mouse
Specificity: Human
Clone: CBXS-1036
Application*: WB, IC, P, C, E

Rabbit Anti-CACYBP Recombinant Antibody (CBXS-1319) (CBMAB-S4178-CQ)

Datasheet SDS
Target: CACYBP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1319
Application*: WB, IP, P, F, IF

Mouse Anti-CACYBP Recombinant Antibody (3G8) (CBMAB-C1140-LY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G8
Application*: WB, E

Mouse Anti-CACYBP Recombinant Antibody (13B93) (CBMAB-C2851-LY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B93
Application*: E, WB

Mouse Anti-CACYBP Recombinant Antibody (7D11) (CBMAB-C8612-LY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D11
Application*: WB, E, P

Mouse Anti-CACYBP Recombinant Antibody (7D11A8) (CBMAB-C8614-LY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D11A8
Application*: E, WB, IH

Mouse Anti-CACYBP Recombinant Antibody (8C53) (CBMAB-C9083-LY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 8C53
Application*: F, C, WB

Rabbit Anti-CACYBP Recombinant Antibody (BA0103) (CBMAB-0132CQ)

Datasheet SDS
Target: CACYBP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0103
Application*: WB, P, IF, IP, F

Mouse Anti-CACYBP Recombinant Antibody (2103C3a) (CBMAB-0133CQ)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2103C3a
Application*: WB, DB

Mouse Anti-CACYBP Recombinant Antibody (AT3G8) (CBMAB-0134CQ)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AT3G8
Application*: WB

Mouse Anti-CACYBP Recombinant Antibody (CBLC056-LY) (CBMAB-C9624-LY)

Datasheet SDS
Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLC056-LY
Application*: F
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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