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CACYBP

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Calcyclin Binding Protein
Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Biological Process
Aging Source: Ensembl
Cardiac muscle cell differentiation Source: Ensembl
Cellular response to calcium ion Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Heart development Source: GO_Central
Negative regulation of cell death Source: Ensembl
Positive regulation of DNA replication Source: Ensembl
Response to growth hormone Source: Ensembl
Cellular Location
Nucleus; Cytoplasm. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
PTM
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
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Anti-CACYBP antibodies

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Rabbit Anti-CACYBP Recombinant Antibody (D43G11) (CBMAB-CP0061-LY)

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Target: CACYBP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D43G11
Application*: WB, P
Datasheet SDS

Mouse Anti-CACYBP Recombinant Antibody (CBLC056-LY) (CBMAB-C9624-LY)

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Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLC056-LY
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-CACYBP Recombinant Antibody (CBYY-C0863) (CBMAB-C2299-YY)

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Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0863
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-CACYBP Recombinant Antibody (7D11) (CBMAB-C8612-LY)

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Target: CACYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D11
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-CACYBP Recombinant Antibody (3G8) (CBMAB-C1140-LY)

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Target: CACYBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G8
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-CACYBP Recombinant Antibody (CBT249) (V2LY-0625-LY3667)

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Target: CACYBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT249
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-CACYBP Recombinant Antibody (CBXS-1036) (CBMAB-S3929-CQ)

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Target: CACYBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-1036
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CACYBP Recombinant Antibody (CBXS-4266) (CBMAB-S1516-CQ)

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Target: CACYBP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-4266
Application*: WB, IP, IF, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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