Mouse Anti-CAMK2G Recombinant Antibody (CBT4011) (V2LY-0625-LY83)

Name: Mouse Anti-CAMK2G Recombinant Antibody (CBT4011)
SKU: V2LY-0625-LY83
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CAMK2G Recombinant Antibody (CBT4011) (V2LY-0625-LY83) in WB

Mouse Anti-CAMK2G Recombinant Antibody (CBT4011) (V2LY-0625-LY83) in FC

Mouse Anti-CAMK2G Recombinant Antibody (CBT4011) (V2LY-0625-LY83) in IHC

Mouse Anti-CAMK2G Recombinant Antibody (CBT4011) (V2LY-0625-LY83) in ELISA

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4011

Application

WB, IHC, FC

Immunogen

Purified recombinant fragment of human CAMK2G (AA: 322-481) expressed in E. Coli.

Host Species

Mouse

Specificity

Human, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Calcium/Calmodulin Dependent Protein Kinase II Gamma

Entrez Gene ID

818

UniProt ID

Q13555

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290).
It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

Biological Process

Cell differentiation Source: UniProtKB-KW
Insulin secretion Source: UniProtKB
Interferon-gamma-mediated signaling pathway Source: Reactome
Nervous system development Source: UniProtKB-KW
Regulation of calcium ion transport Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of neuron projection development Source: UniProtKB
Regulation of skeletal muscle adaptation Source: UniProtKB

Cellular Location

Sarcoplasmic reticulum membrane

Involvement in disease

Intellectual developmental disorder, autosomal dominant 59 (MRD59): An autosomal dominant form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

PTM

Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

Miyauchi, M., Sasaki, K., Taoka, K., Masamoto, Y., Yamazaki, S., Arai, S., & Kurokawa, M. (2018). Calcium/Calmodulin Dependent Protein Kinase 2 Gamma Is Identified As a Potential Therapeutic Target of Myelofibrosis Using Disease-Specific Induced Pluripotent Stem Cells. Blood, 132, 3054.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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