Human Recombinant CAMK2G, Active protein, GST Tag-1 (V2LY-0526-LY2539)

Name: Human Recombinant CAMK2G, Active protein, GST Tag-1
SKU: V2LY-0526-LY2539
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CAMK2G, Active protein, GST Tag consist of Amino Acid: c-terminal truncation and predicts a molecular mass of 60 kDa.

Molecule Mass

60 kDa

Sequence

Amino Acid: c-terminal truncation

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tirs, NaCl, Glycerol, DTT

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Calcium/Calmodulin Dependent Protein Kinase II Gamma

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290).
It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

Biological Process

Cell differentiation Source: UniProtKB-KW
Insulin secretion Source: UniProtKB
Interferon-gamma-mediated signaling pathway Source: Reactome
Nervous system development Source: UniProtKB-KW
Regulation of calcium ion transport Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of neuron projection development Source: UniProtKB
Regulation of skeletal muscle adaptation Source: UniProtKB

Cellular Location

Sarcoplasmic reticulum membrane

Involvement in disease

Intellectual developmental disorder, autosomal dominant 59 (MRD59): An autosomal dominant form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

PTM

Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

Miyauchi, M., Sasaki, K., Taoka, K., Masamoto, Y., Yamazaki, S., Arai, S., & Kurokawa, M. (2018). Calcium/Calmodulin Dependent Protein Kinase 2 Gamma Is Identified As a Potential Therapeutic Target of Myelofibrosis Using Disease-Specific Induced Pluripotent Stem Cells. Blood, 132, 3054.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CAMK2G, Active protein, GST Tag (CAT#: V2LY-0526-LY2538)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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