Sign in or Register   Sign in or Register
  |  

Mouse Anti-CAP1 Recombinant Antibody (CBXC-0059) (CBMAB-C3199-CQ)

This product is a mouse antibody that recognizes CAP1. The antibody CBXC-0059 can be used for immunoassay techniques such as: ELISA, WB.
See all CAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0059
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclase Associated Actin Cytoskeleton Regulatory Protein 1
Introduction
CAP1 (Cyclase Associated Actin Cytoskeleton Regulatory Protein 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by Robo receptor. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAP2.
Entrez Gene ID
10487
UniProt ID
Q01518
Alternative Names
Cyclase Associated Actin Cytoskeleton Regulatory Protein 1; Adenylate Cyclase Associated Protein 1; CAP; CAP, Adenylate Cyclase-Associated Protein 1 (Yeast); Testis Secretory Sperm-Binding Protein Li 218p; CAP, Adenylate Cyclase-Associated Protein 1; Adenylyl Cyclase-Associated Protein 1; CAP1-PEN; CAP 1;
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Biological Process
Actin cytoskeleton organization Source: Ensembl
Activation of adenylate cyclase activity Source: ProtInc
Ameboidal-type cell migration Source: Ensembl
cAMP-mediated signaling Source: GO_Central
Cell morphogenesis Source: GO_Central
Establishment or maintenance of cell polarity Source: ProtInc
Neutrophil degranulation Source: Reactome
Receptor-mediated endocytosis Source: Ensembl
Regulation of adenylate cyclase activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cell membrane

Schneider, F., Duong, T. A., Metz, I., Winkelmeier, J., Hübner, C. A., Endesfelder, U., & Rust, M. B. (2021). Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function. Progress in Neurobiology, 202, 102050.

Zhang, X., Pizzoni, A., Hong, K., Naim, N., Qi, C., Korkhov, V., & Altschuler, D. L. (2021). CAP1 binds and activates adenylyl cyclase in mammalian cells. Proceedings of the National Academy of Sciences, 118(24).

Zhang, H., Ramsey, A., Xiao, Y., Karki, U., Xie, J. Y., Xu, J., ... & Zhou, G. L. (2020). Dynamic phosphorylation and dephosphorylation of cyclase-associated protein 1 by antagonistic signaling through cyclin-dependent kinase 5 and cAMP are critical for the protein functions in actin filament disassembly and cell adhesion. Molecular and cellular biology, 40(4), e00282-19.

Bergqvist, M., Elebro, K., Sandsveden, M., Borgquist, S., & Rosendahl, A. H. (2020). Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer. Breast Cancer Research, 22(1), 1-15.

Yuan, X., Zhen, Z., Zhang, M., Yu, Y., Gao, X., & Ao, J. X. (2019). Cyclase‐associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells. Cell biochemistry and function, 37(3), 185-192.

Hasan, R., & Zhou, G. L. (2019). The cytoskeletal protein cyclase-associated protein 1 (CAP1) in breast cancer: context-dependent roles in both the invasiveness and proliferation of cancer cells and underlying cell signals. International journal of molecular sciences, 20(11), 2653.

Wu, H., Hasan, R., Zhang, H., Gray, J., Williams, D., Miller, M., ... & Zhou, G. L. (2019). Phosphorylation regulates CAP1 (cyclase-associated protein 1) functions in the motility and invasion of pancreatic cancer cells. Scientific reports, 9(1), 1-13.

Kakurina, G. V., Kolegova, E. S., & Kondakova, I. V. (2018). Adenylyl cyclase-associated protein 1: structure, regulation, and participation in cellular processes. Biochemistry (Moscow), 83(1), 45-53.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CAP1 Recombinant Antibody (CBXC-0059)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare