Human CAP1 ELISA Kit (V2LY-0626-LY4322)

Go to compare Compare Online Inquiry
Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0077 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
51.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Cyclase Associated Actin Cytoskeleton Regulatory Protein 1
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Biological Process
Actin cytoskeleton organization Source: Ensembl
Activation of adenylate cyclase activity Source: ProtInc
Ameboidal-type cell migration Source: Ensembl
cAMP-mediated signaling Source: GO_Central
Cell morphogenesis Source: GO_Central
Establishment or maintenance of cell polarity Source: ProtInc
Neutrophil degranulation Source: Reactome
Receptor-mediated endocytosis Source: Ensembl
Regulation of adenylate cyclase activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cell membrane

Schneider, F., Duong, T. A., Metz, I., Winkelmeier, J., Hübner, C. A., Endesfelder, U., & Rust, M. B. (2021). Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function. Progress in Neurobiology, 202, 102050.

Zhang, X., Pizzoni, A., Hong, K., Naim, N., Qi, C., Korkhov, V., & Altschuler, D. L. (2021). CAP1 binds and activates adenylyl cyclase in mammalian cells. Proceedings of the National Academy of Sciences, 118(24).

Zhang, H., Ramsey, A., Xiao, Y., Karki, U., Xie, J. Y., Xu, J., ... & Zhou, G. L. (2020). Dynamic phosphorylation and dephosphorylation of cyclase-associated protein 1 by antagonistic signaling through cyclin-dependent kinase 5 and cAMP are critical for the protein functions in actin filament disassembly and cell adhesion. Molecular and cellular biology, 40(4), e00282-19.

Bergqvist, M., Elebro, K., Sandsveden, M., Borgquist, S., & Rosendahl, A. H. (2020). Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer. Breast Cancer Research, 22(1), 1-15.

Yuan, X., Zhen, Z., Zhang, M., Yu, Y., Gao, X., & Ao, J. X. (2019). Cyclase‐associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells. Cell biochemistry and function, 37(3), 185-192.

Hasan, R., & Zhou, G. L. (2019). The cytoskeletal protein cyclase-associated protein 1 (CAP1) in breast cancer: context-dependent roles in both the invasiveness and proliferation of cancer cells and underlying cell signals. International journal of molecular sciences, 20(11), 2653.

Wu, H., Hasan, R., Zhang, H., Gray, J., Williams, D., Miller, M., ... & Zhou, G. L. (2019). Phosphorylation regulates CAP1 (cyclase-associated protein 1) functions in the motility and invasion of pancreatic cancer cells. Scientific reports, 9(1), 1-13.

Kakurina, G. V., Kolegova, E. S., & Kondakova, I. V. (2018). Adenylyl cyclase-associated protein 1: structure, regulation, and participation in cellular processes. Biochemistry (Moscow), 83(1), 45-53.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Human CAP1 ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.