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Mouse Anti-CAPG Recombinant Antibody (CBYC-A928) (CBMAB-A4274-YC)

Provided herein is a Mouse monoclonal antibody against Human Capping Actin Protein, Gelsolin Like. The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all CAPG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-A928
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Capping Actin Protein, Gelsolin Like
Introduction
CAPG (Capping Actin Protein, Gelsolin Like) is a protein coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and protein complex binding. And an important paralog of this gene is GSN.
Entrez Gene ID
822
UniProt ID
P40121
Alternative Names
Capping Actin Protein, Gelsolin Like; Capping Protein (Actin Filament), Gelsolin-Like; AFCP; MCP; Epididymis Secretory Protein Li 66; Actin-Regulatory Protein CAP-G;
Function
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
Biological Process
Actin filament severing Source: GO_Central
Actin polymerization or depolymerization Source: GO_Central
Barbed-end actin filament capping Source: GO_Central
Cell projection assembly Source: GO_Central
Central nervous system development Source: GO_Central
Protein-containing complex assembly Source: ProtInc
Cellular Location
Nucleus; Cytoplasm; Melanosome; Lamellipodium; Ruffle. In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia.
PTM
The N-terminus is blocked.

Prescher, N., Hänsch, S., Knobbe-Thomsen, C. B., Stühler, K., & Poschmann, G. (2021). The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG. Free Radical Biology and Medicine, 167, 81-93.

Bahrami, S., Gheysarzadeh, A., Sotoudeh, M., Bandehpour, M., Zali, H., Hedayati, M., & Basiri, A. (2020). The Association Between Gelsolin-like Actin-capping Protein (CapG) Overexpression and Bladder Cancer Prognosis. Urology journal, 5664-5664.

Wei, J., Feng, L., & Wu, L. (2020). Integrated analysis identified CAPG as a prognosis factor correlated with immune infiltrates in lower‐grade glioma. Clinical and translational medicine, 10(2).

Zhaojie, L., Yuchen, L., Miao, C., Yacun, C., Shayi, W., Anbang, H., ... & Xinyuan, G. (2019). Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition via the Hippo signaling pathway in human bladder cancer. Therapeutic advances in medical oncology, 11, 1758835919841235.

Lang, Z., Chen, Y., Zhu, H., Sun, Y., Zhang, H., Huang, J., & Zou, Z. (2019). Prognostic and clinicopathological significance of CapG in various cancers: Evidence from a meta-analysis. Pathology-Research and Practice, 215(12), 152683.

Yun, D. P., Wang, Y. Q., Meng, D. L., Ji, Y. Y., Chen, J. X., Chen, H. Y., & Lu, D. R. (2018). Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncology reports, 39(3), 1011-1022.

Tsai, T. J., Chao, W. Y., Chen, C. C., Chen, Y. J., Lin, C. Y., & Lee, Y. R. (2018). Gelsolin-like Actin-capping Protein (CapG) Overexpression in the Cytoplasm of Human Hepatocellular Carcinoma, Associated with Cellular Invasion, Migration and Tumor Prognosis. Anticancer research, 38(7), 3943-3950.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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