Rabbit Anti-CAPNS1 Recombinant Antibody (CBFYC-0803) (CBMAB-C0858-FY)

Name: Rabbit Anti-CAPNS1 Recombinant Antibody (CBFYC-0803)
SKU: CBMAB-C0858-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYC-0803

Application

WB, IHC-P, FC

Immunogen

Recombinant protein within Human Calpain small subunit 1 aa 1-140.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000
IHC-P	1:50-1:200
FC	1:50-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

TBS, pH 7.4, 40% glycerol, 0.05% BSA

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

calpain, small subunit 1

Introduction

CAPNS1 (Calpain Small Subunit 1) is a Protein Coding gene. Diseases associated with CAPNS1 include Chronic Neutrophilic Leukemia. Among its related pathways are Apoptosis Modulation and Signaling and Keratinization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPNS2.

Entrez Gene ID

Human	826
Cattle	281664

UniProt ID

Human	P04632
Cattle	P13135

Alternative Names

Calpain Small Subunit 1; Calcium-Activated Neutral Proteinase Small Subunit; Calcium-Dependent Protease Small Subunit 1; Calpain Regulatory Subunit; CANP Small Subunit; CAPN4; CSS1; CDPS; Calcium-Dependent Protease, Small Subunit

Function

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Biological Process

Cornification Source: Reactome
Extracellular matrix disassembly Source: Reactome
Positive regulation of cell population proliferation Source: ProtInc
Regulation of macroautophagy Source: ParkinsonsUK-UCL

Cellular Location

Cytoplasm; Cell membrane. Translocates to the plasma membrane upon calcium binding.

Wang, J., Ciampa, G., Zheng, D., Shi, Q., Chen, B., Abel, E. D., ... & Song, L. S. (2021). Calpain-2 Specifically Cleaves Junctophilin-2 at the Same Site as Calpain-1 but with Less Efficacy. Biochemical Journal.

Zhuang, Q., Fan, M., Shen, J., Chen, Z., Xue, D., Lu, H., ... & Hou, J. (2021). Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma. Urologia internationalis, 1-8.

Tang, S., Yin, Q., Liu, F., & Zhang, Y. (2019). Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation. BioMed research international, 2019.

MacLeod, J. A., Gao, Y., Hall, C., Muller, W. J., Gujral, T. S., & Greer, P. A. (2018). Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. Oncotarget, 9(70), 33382.

Grochowska, E., Borys, B., Grześkowiak, E., & Mroczkowski, S. (2017). Effect of the calpain small subunit 1 gene (CAPNS1) polymorphism on meat quality traits in sheep. Small Ruminant Research, 150, 15-21.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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