CAPNS1

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Full Name
calpain, small subunit 1
Function
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Biological Process
Cornification Source: Reactome
Extracellular matrix disassembly Source: Reactome
Positive regulation of cell population proliferation Source: ProtInc
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Cellular Location
Cytoplasm; Cell membrane. Translocates to the plasma membrane upon calcium binding.
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Anti-CAPNS1 antibodies

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Rabbit Anti-CAPNS1 Recombinant Antibody (C9695) (CBMAB-C9695-LY)

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Target: CAPNS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C9695
Application*: WB, IH, F, IF
Datasheet SDS

Rabbit Anti-CAPNS1 Recombinant Antibody (CBFYC-0803) (CBMAB-C0858-FY)

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Target: CAPNS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0803
Application*: WB, P, F
Datasheet SDS

Mouse Anti-CAPNS1 Recombinant Antibody (CBFYC-0802) (CBMAB-C0857-FY)

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Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0802
Application*: IP, IF, WB
Datasheet SDS

Mouse Anti-CAPNS1 Recombinant Antibody (156) (CBMAB-C3217-LY)

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Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human
Clone: 156
Application*: IF, WB
Datasheet SDS

Mouse Anti-CAPNS1 Monoclonal Antibody (1D11) (CBMAB-0951-YC)

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Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D11
Application*: E, WB, IF
Datasheet SDS

Human CAPNS1 ELISA Kit (V2LY-0626-LY4063)

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Target: CAPNS1
Sensitivity: 0.02 ng/mL
Detection Range: 0.05-15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-CAPNS1 Recombinant Antibody (CBLNC-140) (CBMAB-1312-CN)

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Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBLNC-140
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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