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CAPNS1

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]

Full Name

calpain, small subunit 1

Function

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Biological Process

Cornification Source: Reactome
Extracellular matrix disassembly Source: Reactome
Positive regulation of cell population proliferation Source: ProtInc
Regulation of macroautophagy Source: ParkinsonsUK-UCL

Cellular Location

Cytoplasm; Cell membrane. Translocates to the plasma membrane upon calcium binding.

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Anti-CAPNS1 antibodies

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Rabbit Anti-CAPNS1 Recombinant Antibody (C9695) (CBMAB-C9695-LY)

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Target: CAPNS1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: C9695

Application*: WB, IH, F, IF

Rabbit Anti-CAPNS1 Recombinant Antibody (CBFYC-0803) (CBMAB-C0858-FY)

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Target: CAPNS1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-0803

Application*: WB, P, F

Mouse Anti-CAPNS1 Recombinant Antibody (CBFYC-0802) (CBMAB-C0857-FY)

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Target: CAPNS1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYC-0802

Application*: IP, IF, WB

Mouse Anti-CAPNS1 Recombinant Antibody (156) (CBMAB-C3217-LY)

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Target: CAPNS1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human

Clone: 156

Application*: IF, WB

Mouse Anti-CAPNS1 Monoclonal Antibody (1D11) (CBMAB-0951-YC)

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Target: CAPNS1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D11

Application*: E, WB, IF

Mouse Anti-CAPNS1 Recombinant Antibody (CBLNC-140) (CBMAB-1312-CN)

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Target: CAPNS1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: CBLNC-140

Application*: WB, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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