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Mouse Anti-CBX2 Recombinant Antibody (CBYY-C1035) (CBMAB-C2472-YY)

This product is mouse antibody that recognizes CBX2. The antibody CBYY-C1035 can be used for immunoassay techniques such as: ELISA, WB
See all CBX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1035
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa66-166 from human CBX2 (NP_116036) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CBX2
Entrez Gene ID
84733
UniProt ID
Q14781
Alternative Names
C-C Motif Chemokine Ligand 17; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17; Thymus And Activation-Regulated Chemokine; Chemokine (C-C Motif) Ligand 17; Small-Inducible Cytokine A17; CC Chemokine TARC; SCYA17;
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530).
Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity).
Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity).
Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).
Biological Process
Cell differentiation Source: UniProtKB-KW
Chromatin organization Source: UniProtKB-KW
Development of primary sexual characteristics Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus; Chromosome. Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin.
Involvement in disease
46,XY sex reversal 5 (SRXY5): A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.

Zhu, J., Luo, J. E., Chen, Y., & Wu, Q. (2021). Circ_0061140 knockdown inhibits tumorigenesis and improves PTX sensitivity by regulating miR-136/CBX2 axis in ovarian cancer. Journal of ovarian research, 14(1), 1-12.

Ueda, S., Kanda, M., Sato, Y., Baba, H., Nakamura, S., Sawaki, K., ... & Nomoto, S. (2020). Chromobox 2 expression predicts prognosis after curative resection of oesophageal squamous cell carcinoma. Cancer Genomics & Proteomics, 17(4), 391-400.

Wang, W., Li, X., Guan, C., Hu, Z., Zhao, Y., Li, W., & Jiang, X. (2020). LncRNA PCAT6 promotes the proliferation, migration and invasion of pancreatic ductal adenocarcinoma via regulating miR-185-5p/CBX2 axis. Pathology-Research and Practice, 216(9), 153074.

Tatavosian, R., Kent, S., Brown, K., Yao, T., Duc, H. N., Huynh, T. N., ... & Ren, X. (2019). Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation. Journal of Biological Chemistry, 294(5), 1451-1463.

Wheeler, L. J., Watson, Z. L., Qamar, L., Yamamoto, T., Behbakht, K., & Bitler, B. G. (2019). Chromobox 2 protein identified as driver of anoikis-escape and disease progression in high grade serous ovarian cancer. Gynecologic Oncology, 154(1), e25-e26.

Mao, J., Tian, Y., Wang, C., Jiang, K., Li, R., Yao, Y., ... & Wang, L. (2019). CBX2 regulates proliferation and apoptosis via the phosphorylation of YAP in hepatocellular carcinoma. Journal of Cancer, 10(12), 2706.

Sun, D., Cao, X., & Wang, C. (2019). Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter. Protein & cell, 10(4), 285-294.

Wheeler, L. J., Watson, Z. L., Qamar, L., Yamamoto, T. M., Post, M. D., Berning, A. A., ... & Bitler, B. G. (2018). CBX2 identified as driver of anoikis escape and dissemination in high grade serous ovarian cancer. Oncogenesis, 7(11), 1-14.

Sproll, P., Eid, W., Gomes, C. R., Mendonca, B. B., Gomes, N. L., Costa, E. M. F., & Biason‐Lauber, A. (2018). Assembling the jigsaw puzzle: CBX 2 isoform 2 and its targets in disorders/differences of sex development. Molecular genetics & genomic medicine, 6(5), 785-795.

Chen, W. Y., Zhang, X. Y., Liu, T., Liu, Y., Zhao, Y. S., & Pang, D. (2017). Chromobox homolog 2 protein: A novel biomarker for predicting prognosis and Taxol sensitivity in patients with breast cancer. Oncology letters, 13(3), 1149-1156.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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