CBX2

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
Full Name
CBX2
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530).
Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity).
Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity).
Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).
Biological Process
Cell differentiation Source: UniProtKB-KW
Chromatin organization Source: UniProtKB-KW
Development of primary sexual characteristics Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus; Chromosome. Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin.
Involvement in disease
46,XY sex reversal 5 (SRXY5): A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.
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Anti-CBX2 antibodies

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Mouse Anti-CBX2 Recombinant Antibody (880833) (CBMAB-C9001-LY)

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Target: CBX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 880833
Application*: IC
Datasheet SDS

Mouse Anti-CBX2 Recombinant Antibody (4C11B10) (CBMAB-C6717-LY)

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Target: CBX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 4C11B10
Application*: E, WB, P, IF/C, F
Datasheet SDS

Mouse Anti-CBX2 Recombinant Antibody (1E9) (CBMAB-C3989-LY)

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Target: CBX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 1E9
Application*: E, WB
Datasheet SDS

Mouse Anti-CBX2 Recombinant Antibody (CBT3835) (V2LY-0625-LY326)

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Target: CBX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3835
Application*: WB
Datasheet SDS

Mouse Anti-CBX2 Recombinant Antibody (CBT2529) (V2LY-0625-LY325)

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Target: CBX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT2529
Application*: WB, IH, IC, F
Datasheet SDS

Rabbit Anti-CBX2 Recombinant Antibody (CBYY-C1037) (CBMAB-C2474-YY)

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Target: CBX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C1037
Application*: WB, IP, IF
Datasheet SDS

Rabbit Anti-CBX2 Recombinant Antibody (CBYY-C1036) (CBMAB-C2473-YY)

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Target: CBX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYY-C1036
Application*: WB, IP
Datasheet SDS

Mouse Anti-CBX2 Recombinant Antibody (CBYY-C1035) (CBMAB-C2472-YY)

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Target: CBX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C1035
Application*: E, WB
Datasheet SDS

Mouse Anti-CBX2 Recombinant Antibody (CBFYM-0897) (CBMAB-M1045-FY)

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Target: CBX2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBFYM-0897
Application*: E, WB, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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