Mouse Anti-CBX6 Recombinant Antibody (CBT3664) (V2LY-0625-LY290)

Name: Mouse Anti-CBX6 Recombinant Antibody (CBT3664)
SKU: V2LY-0625-LY290
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CBX6 Recombinant Antibody (CBT3664) (V2LY-0625-LY290) in ELISA

Mouse Anti-CBX6 Recombinant Antibody (CBT3664) (V2LY-0625-LY290) in WB

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT3664

Immunogen

Purified recombinant fragment of human CBX6 (AA: 269-412) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Chromobox 6

Entrez Gene ID

23466

UniProt ID

O95503

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235).
Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity).
May have a PRC1-independent function in embryonic stem cells (By similarity).

Biological Process

Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus; Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).

Li, F., Sun, X., Liu, Q., Liu, X., & Zhang, J. (2021). Long Noncoding RNA MIR100HG Knockdown Attenuates Hepatocellular Carcinoma Progression by Regulating MicroRNA-146b-5p/Chromobox 6. Gastroenterology Research and Practice, 2021.

Sakai, K., Nishiuchi, T., Tange, S., Suzuki, Y., Yano, S., Terashima, M., ... & Matsumoto, K. (2020). Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion. Scientific reports, 10(1), 1-16.

Wang, J., He, H., Jiang, Q., Wang, Y., & Jia, S. (2020). CBX6 Promotes HCC Metastasis Via Transcription Factors Snail/Zeb1-Mediated EMT Mechanism. OncoTargets and therapy, 13, 12489.

Deng, H., Guan, X., Gong, L., Zeng, J., Zhang, H., Chen, M. Y., & Li, G. (2019). CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer. Scientific reports, 9(1), 1-13.

Ning, G., Huang, Y. L., Zhen, L. M., Xu, W. X., Jiao, Q., Yang, F. J., ... & Peng, L. (2018). Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients. Aging (Albany NY), 10(11), 3450.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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