Mouse Anti-CBX6 Recombinant Antibody (8D10A3) (CBMAB-C9118-LY)

Name: Mouse Anti-CBX6 Recombinant Antibody (8D10A3)
SKU: CBMAB-C9118-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

8D10A3

Antibody Isotype

IgG1

Application

ELISA, WB

Basic Information

Immunogen

Purified recombinant fragment of human CBX6 (AA: 269-412) expressed in E. coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:10,000
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Chromobox 6

Introduction

CBX6 (Chromobox 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX8.

Entrez Gene ID

23466

UniProt ID

O95503

Alternative Names

Chromobox 6; Chromobox Homolog 6;

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235).
Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity).
May have a PRC1-independent function in embryonic stem cells (By similarity).

Biological Process

Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus; Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).

More Infomation

References

Li, F., Sun, X., Liu, Q., Liu, X., & Zhang, J. (2021). Long Noncoding RNA MIR100HG Knockdown Attenuates Hepatocellular Carcinoma Progression by Regulating MicroRNA-146b-5p/Chromobox 6. Gastroenterology Research and Practice, 2021.

Sakai, K., Nishiuchi, T., Tange, S., Suzuki, Y., Yano, S., Terashima, M., ... & Matsumoto, K. (2020). Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion. Scientific reports, 10(1), 1-16.

Wang, J., He, H., Jiang, Q., Wang, Y., & Jia, S. (2020). CBX6 Promotes HCC Metastasis Via Transcription Factors Snail/Zeb1-Mediated EMT Mechanism. OncoTargets and therapy, 13, 12489.

Deng, H., Guan, X., Gong, L., Zeng, J., Zhang, H., Chen, M. Y., & Li, G. (2019). CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer. Scientific reports, 9(1), 1-13.

Ning, G., Huang, Y. L., Zhen, L. M., Xu, W. X., Jiao, Q., Yang, F. J., ... & Peng, L. (2018). Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients. Aging (Albany NY), 10(11), 3450.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CBX6 Recombinant Antibody (CBXC-3090)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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