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Mouse Anti-CBX6 Recombinant Antibody (8D10A3) (CBMAB-C9118-LY)

This product is antibody recognizes CBX6. The antibody 8D10A3 immunoassay techniques such as: WB, FC, ELISA, IHC, ICC, CyTOF.
See all CBX6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8D10A3
Antibody Isotype
IgG
Application
WB, FC, ELISA, IHC, ICC, CyTOF

Basic Information

Immunogen
Purified recombinant fragment of human CBX6 (AA: 269-412) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chromobox 6
Introduction
CBX6 (Chromobox 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX8.
Entrez Gene ID
23466
UniProt ID
O95503
Alternative Names
Chromobox 6; Chromobox Homolog 6;
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235).
Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity).
May have a PRC1-independent function in embryonic stem cells (By similarity).
Biological Process
Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus; Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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