CBX6

CBX6 (Chromobox 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX8.

Chromobox 6

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235).
Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity).
May have a PRC1-independent function in embryonic stem cells (By similarity).

Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB

Nucleus; Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).