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CBX6

CBX6 (Chromobox 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX8.

Full Name

Chromobox 6

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235).
Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity).
May have a PRC1-independent function in embryonic stem cells (By similarity).

Biological Process

Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus; Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).

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Anti-CBX6 antibodies

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Mouse Anti-CBX6 Recombinant Antibody (8D10A3) (CBMAB-C9118-LY)

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Target: CBX6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8D10A3

Application*: E, WB

Mouse Anti-CBX6 Recombinant Antibody (CBT3664) (V2LY-0625-LY290)

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Target: CBX6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3664

Mouse Anti-CBX6 Recombinant Antibody (CBXC-3090) (CBMAB-C0358-CQ)

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Target: CBX6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat, Horse, Dog, Cattle

Clone: CBXC-3090

Application*: WB, IF, E, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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