CBX6

CBX6 (Chromobox 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX8.
Full Name
Chromobox 6
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530).
PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235).
Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity).
May have a PRC1-independent function in embryonic stem cells (By similarity).
Biological Process
Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus; Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).
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Anti-CBX6 antibodies

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Mouse Anti-CBX6 Recombinant Antibody (8D10A3) (CBMAB-C9118-LY)

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Target: CBX6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D10A3
Application*: E, WB
Datasheet SDS

Mouse Anti-CBX6 Recombinant Antibody (CBT3664) (V2LY-0625-LY290)

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Target: CBX6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3664
Datasheet SDS

Mouse Anti-CBX6 Recombinant Antibody (CBXC-3090) (CBMAB-C0358-CQ)

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Target: CBX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle
Clone: CBXC-3090
Application*: WB, IF, E, IP
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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