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Rat Anti-CCL21 Recombinant Antibody (CBFYC-0957) (CBMAB-C1013-FY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-0957
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant mouse CCL21/6Ckine Ser24-Gly133.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 21
Introduction
CCL21 (C-C Motif Chemokine Ligand 21) is a Protein Coding gene. Diseases associated with CCL21 include Posterolateral Myocardial Infarction and Thymic Hyperplasia. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and CCR7 chemokine receptor binding.
Entrez Gene ID
298006
UniProt ID
Q5RJN3
Alternative Names
Ccl21b
Function
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Biological Process
Activation of GTPase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell chemotaxis Source: UniProtKB
Cell maturation Source: BHF-UCL
Cellular response to chemokine Source: BHF-UCL
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine (C-C motif) ligand 21 signaling pathway Source: BHF-UCL
Chemokine-mediated signaling pathway Source: GO_Central
Dendritic cell chemotaxis Source: BHF-UCL
Dendritic cell dendrite assembly Source: BHF-UCL
Eosinophil chemotaxis Source: GO_Central
Establishment of T cell polarity Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: ProtInc
Immunological synapse formation Source: BHF-UCL
Inflammatory response Source: GO_Central
Lilling of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Mesangial cell-matrix adhesion Source: BHF-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Negative regulation of dendritic cell dendrite assembly Source: BHF-UCL
Negative regulation of leukocyte tethering or rolling Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of cell motility Source: BHF-UCL
Positive regulation of chemotaxis Source: BHF-UCL
Positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of myeloid dendritic cell chemotaxis Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of pseudopodium assembly Source: BHF-UCL
Positive regulation of receptor-mediated endocytosis Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Positive regulation of T cell migration Source: MGI
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to prostaglandin E Source: BHF-UCL
Ruffle organization Source: BHF-UCL
T cell costimulation Source: BHF-UCL
Cellular Location
Secreted
More Infomation

Chen, Q., Yin, H., Pu, N., Zhang, J., Zhao, G., Wenhui, L., & Wu, W. (2021). CCL21 synergized with PD-L1 blockade restrains tumor growth. Cancer Science.

Chen, Q., Yin, H., Pu, N., Zhang, J., Zhao, G., Lou, W., & Wu, W. (2021). Chemokine C‐C motif ligand 21 synergized with programmed death‐ligand 1 blockade restrains tumor growth. Cancer science, 112(11), 4457-4469.

Cui, K., Zou, H., Shi, M., Ou, Y., Han, L., Zhang, B., ... & Li, S. (2020). Gene expression profiles in chemokine (CC Motif) Ligand 21-Overexpressing pancreatic cancer cells. Pathology & Oncology Research, 26(1), 201-208.

Liu, B., Lisberg, A., Salehi-Rad, R., Lee, J. M., Tran, L. M., Krysan, K., ... & Dubinett, S. M. (2020). A33 Phase I Trial of in Situ Vaccination with Autologous CCL21-Modified Dendritic Cells (CCL21-DC) Combined with Pembrolizumab for Advanced NSCLC. Journal of Thoracic Oncology, 15(2), S23.

Liu, M. Z., Chen, S. M., Xu, Y., Kong, Y. G., Deng, Y. Q., Li, F., & Tao, Z. Z. (2020). Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps. International archives of allergy and immunology, 181(3), 159-169.

Ju, Y., Sun, C., & Wang, X. (2019). Loss of atypical chemokine receptor 4 facilitates C‑C motif chemokine ligand 21‑mediated tumor growth and invasion in nasopharyngeal carcinoma. Experimental and therapeutic medicine, 17(1), 613-620.

Bae, H., Lim, W., Bazer, F. W., Whang, K. Y., & Song, G. (2019). Mitigation of ER-stress and inflammation by chemokine (CC motif) ligand 21 during early pregnancy. Developmental & Comparative Immunology, 94, 73-84.

Hong, C. H., Lin, S. H., & Lee, C. H. (2019). CCL21 induces mTOR-dependent MALAT1 expression, leading to cell migration in cutaneous T-cell lymphoma. in vivo, 33(3), 793-800.

Liu, L., Zhao, L., Yang, Y., Gao, J., Hu, C., Guo, B., & Zhu, B. (2018). Cytotoxic chemotherapy reduces T cell trafficking to the spleen by downregulating the expression of C‑C motif chemokine ligand 21 and C‑C motif chemokine ligand 19. Oncology letters, 16(4), 5013-5019.

Zhong, G., Chen, L., Yin, R., Qu, Y., Bao, Y., Xiao, Q., ... & Tian, H. (2017). Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway. Molecular medicine reports, 15(6), 4100-4108.

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For research use only. Not intended for any clinical use.

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